Thermo Fisher Scientific PYK2 Polyclonal Antibody
Rabbit polyclonal antibody against PYK2 (PTK2B) for Western blot and immunoprecipitation. Recognizes human PYK2, predicted to cross-react with mouse and rat. Supplied as liquid, 1 mg/mL, stored at 4 °C. For research use only.
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Applications
| Application | Tested Dilution |
|---|---|
| Western Blot (WB) | 1:2,000–1:10,000 |
| Immunoprecipitation (IP) | 2–10 µg/mg lysate |
Product Specifications
| Property | Description |
|---|---|
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | Region between residue 959–1009 of Human Protein Tyrosine Kinase 2 beta (PTK2B) |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 1 mg/mL |
| Storage Conditions | 4 °C |
| Shipping Conditions | Wet ice |
Product Specific Information
- Recommended shelf life: 1 year from date of receipt
- Based on 100% sequence identity, this antibody is predicted to react with Mouse and Rat
Target Information
PTK2B (FAK2) is a cytoplasmic tyrosine kinase involved in calcium-induced regulation of ion channels and activation of the MAP kinase signaling pathway. It regulates actin cytoskeleton reorganization, cell polarization, migration, adhesion, spreading, and bone remodeling.
FAK2 also contributes to humoral immune response regulation and B-cell migration in the spleen. It functions downstream of integrin, collagen, immune, GPCR, cytokine, chemokine, and growth factor receptors, mediating responses to cellular stress.
Aberrant FAK2 expression may be associated with cancer cell proliferation, migration, and invasion, with elevated expression observed in gliomas, hepatocellular carcinoma, lung cancer, and breast cancer.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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