Thermo Fisher Scientific FOLR3 Monoclonal Antibody (OTI7E10), TrueMAB

Applications

• Western Blot (WB): 1:2,000
• Immunohistochemistry (Paraffin) (IHC (P)): 1:2,000

Product Specifications

Product Specific Information

For reconstitution, add 100 µL distilled water to obtain a final antibody concentration of about 1 mg/mL.
For conjugation experiments, perform desalting using Zeba Spin Desalting Columns, 7K MWCO, 0.5 mL (Product #89882).

Target Information

Folate is an essential vitamin obtained through intestinal absorption in mammals. Folate and its derivatives bind to the folate receptor (FR) family, mediating endocytosis of 5-methyltetrahydrofolate into cells.
The FR family includes five members: alpha, beta, gamma, gamma′ (alternative splicing variant), and delta.

• β-FR: Membrane-bound via GPI anchor; expressed in malignant epithelial and non-epithelial tissues.
• γ-FR: Found in hematopoietic tissues such as spleen, thymus, and bone marrow.
• δ-FR: Expression pattern is highly restricted.
• α-FR: Used as a selective tumor marker and can deliver therapeutic compounds to tumor cells via folic acid derivatives.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.

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