Thermo Fisher Scientific NALP12 Polyclonal Antibody
NALP12 단백질을 인식하는 Thermo Fisher Scientific의 Rabbit Polyclonal Antibody. IHC, ICC/IF, ELISA 등 다양한 응용에 적합. Human, Mouse, Rat 반응성. Protein A로 정제된 고품질 항체로 연구용 사용에 적합.
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Applications and Tested Dilutions
| Application | Tested Dilution |
|---|---|
| Immunohistochemistry (Paraffin) (IHC (P)) | 1:200 |
| Immunohistochemistry (Frozen) (IHC (F)) | 1:100–1:500 |
| Immunocytochemistry (ICC/IF) | 1:50–1:200 |
| ELISA | 1:500–1:1,000 |
Product Specifications
| Specification | Description |
|---|---|
| Species Reactivity | Human, Mouse, Rat |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | KLH conjugated synthetic peptide derived from human NALP12 (amino acids 176–270) |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 1 mg/mL |
| Purification | Protein A |
| Storage Buffer | 0.01M TBS, pH 7.4, with 1% BSA, 50% glycerol |
| Contains | 0.02% ProClin 300 |
| Storage Conditions | -20°C |
| Shipping Conditions | Ambient (domestic); Wet ice (international) |
Target Information
NALP proteins are cytoplasmic proteins that form a subfamily within the larger CATERPILLER family and play a crucial role in cell proliferation and reproduction.
NALP12 (Monarch-1) includes a C-terminal leucine-rich repeat (LRR) region, an N-terminal Pyrin domain (PYD), a NACHT domain, and a NACHT-associated domain.
NALP12 acts as an attenuating factor of inflammation by suppressing NF-kappa-B activation through TLR-signaling molecules (MyD88, IRAK-1, TRAF6, RIPK1) in activated monocytes.
Mutations in NALP12 are associated with hereditary periodic fever syndromes.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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