Thermo Fisher Scientific ILP2 Polyclonal Antibody
ILP2 단백질을 인식하는 Rabbit Polyclonal 항체로, Human, Mouse, Rat 시료에 반응합니다. IHC, ICC/IF, ELISA 등 다양한 응용에 적합하며, Protein A로 정제된 1 mg/mL 농도의 액상 형태입니다. 연구용으로만 사용 가능합니다.
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Applications and Tested Dilution
| Application | Tested Dilution |
|---|---|
| Immunohistochemistry (Paraffin) (IHC (P)) | Assay-dependent |
| Immunohistochemistry (Frozen) (IHC (F)) | 1:100–1:500 |
| Immunocytochemistry (ICC/IF) | 1:50–1:200 |
| ELISA | 1:500–1:1,000 |
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human, Mouse, Rat |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | KLH conjugated synthetic peptide derived from human ILP2, amino acids 141–236 |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 1 mg/mL |
| Purification | Protein A |
| Storage Buffer | 0.01M TBS, pH 7.4, with 1% BSA, 50% glycerol |
| Contains | 0.02% ProClin 300 |
| Storage Conditions | -20°C |
| Shipping Conditions | Ambient (domestic); Wet ice (international) |
Target Information
Apoptosis, or programmed cell death, is related to many diseases such as cancer. Apoptosis is triggered by various stimuli including TNF family members and inhibited by IAP (inhibitor of apoptosis) proteins. IAP proteins form a conserved gene family including IAP, XIAP/ILP-1/MIHA, and Livin/KIAP, which bind to and inhibit specific proteases.
A novel member of the IAP protein family, ILP-2 (IAP-like protein-2), has high homology to ILP-1 but is encoded by a distinct gene expressed solely in the testis of normal human tissues. Unlike ILP-1, ILP-2 does not inhibit Fas or TNF-induced apoptosis but strongly inhibits apoptosis induced by Bax overexpression or coexpression of caspase-9 with Apaf-1. ILP-2 interacts with processed caspase-9, suggesting that ILP-2 is a novel IAP family member with restricted specificity for caspase-9.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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