Thermo Fisher Scientific Major Basic Protein (PRG2) Monoclonal Antibody (OTI1C12)
인간 PRG2 단백질(아미노산 17-222)에 특이적인 단일클론 항체로, Western blot에 최적화됨. 무보존제, 동결건조 형태로 제공되며 재구성 후 1 mg/mL 농도 유지. 친화 크로마토그래피로 정제되어 연구용으로 사용 가능.
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Thermo Fisher Scientific Major Basic Protein (PRG2) Monoclonal Antibody (OTI1C12)
Applications
- Western Blot (WB)
Tested Dilution: 1:500
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human |
| Host / Isotype | Mouse / IgG2a |
| Class | Monoclonal |
| Type | Antibody |
| Clone | OTI1C12 |
| Immunogen | Human recombinant protein fragment corresponding to amino acids 17–222 of human PRG2 (NP_002719) produced in E. coli |
| Conjugate | Unconjugated |
| Form | Lyophilized |
| Concentration | 1 mg/mL |
| Purification | Affinity chromatography |
| Storage buffer | PBS with 8% trehalose |
| Contains | No preservative |
| Storage conditions | -20°C |
| Shipping conditions | Ambient (domestic); Wet ice (international) |
Product Specific Information
For reconstitution, add 100 µL distilled water to achieve a final antibody concentration of approximately 1 mg/mL.
For conjugation experiments using this carrier-free antibody, perform an additional desalting step (e.g., Zeba Spin Desalting Columns, 7K MWCO, 0.5 mL, Product #89882).
Target Information
The protein encoded by PRG2 is the predominant constituent of the crystalline core of eosinophil granules. High levels of its proform are found in placenta and pregnancy serum, forming complexes with proteins such as PAPPA, AGT, and C3dg.
This protein plays roles in antiparasitic defense mechanisms as a cytotoxin and helminthotoxin, and contributes to immune hypersensitivity reactions. It is implicated in epithelial cell damage, exfoliation, and bronchospasm in allergic diseases.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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