Thermo Fisher Scientific SORT1 Monoclonal Antibody (OTI3H4), TrueMAB
Human, Mouse, Rat에서 반응하는 SORT1 단클론 항체로 Western Blot에 적합. Lyophilized 형태이며 PBS buffer에 trehalose 포함. 단백질 수송 및 신경세포 사멸 연구용으로 사용. 연구용으로만 사용 가능.
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Applications
- Western Blot (WB): 1:500
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human, Mouse, Rat |
| Host / Isotype | Mouse / IgG1 |
| Class | Monoclonal |
| Type | Antibody |
| Clone | OTI3H4 |
| Immunogen | Human recombinant protein fragment corresponding to amino acids 34–300 of human SORT1 produced in E. coli |
| Conjugate | Unconjugated |
| Form | Lyophilized |
| Concentration | 1 mg/mL |
| Purification | Affinity chromatography |
| Storage Buffer | PBS, pH 7.3, with 8% trehalose |
| Contains | No preservative |
| Storage Conditions | -20°C, Avoid Freeze/Thaw Cycles |
| Shipping Conditions | Ambient (domestic); Wet ice (international) |
Product Specific Information
For reconstitution, add 100 µL distilled water to achieve a final antibody concentration of approximately 1 mg/mL.
For conjugation experiments, perform an additional desalting step using Zeba Spin Desalting Columns (7K MWCO, 0.5 mL, Product #89882).
Target Information
Sortilin functions as a sorting receptor in the Golgi compartment and as a clearance receptor on the cell surface.
It is required for protein transport from the Golgi apparatus to lysosomes via a pathway independent of the mannose-6-phosphate receptor (M6PR) and also for transport to endosomes.
Sortilin promotes neuronal apoptosis by mediating endocytosis of the proapoptotic precursor forms of BDNF (proBDNF) and NGFB (proNGFB), and also acts as a receptor for neurotensin.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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