Thermo Fisher Scientific Calumenin Polyclonal Antibody

Applications

Tested Dilution

Publications

Immunocytochemistry (ICC/IF)

1:50-1:100

-

ELISA (ELISA)

1 µg/mL

-

Product Specifications

Species Reactivity

Human, Rat

Host/Isotype

Rabbit / IgG

Class

Polyclonal

Type

Antibody

Immunogen

Recombinant fusion protein containing a sequence corresponding to amino acids 20-315 of human CALU (NP_0012101) if (typeof window.$mangular === undefined || !window.$mangular) { window.$mangular = {}; } $mangular.antigenJson = \[{targetFamily:Calumenin,uniProtId:O43852-1,ncbiNodeId:9606,antigenRange:20-315,antigenLength:315,antigenImageFileName:PA5-88528_Calumenin_O43852-1_Rabbit.svg,antigenImageFileNamePDP:PA5-88528_Calumenin_O43852-1_Rabbit_PDP.jpeg,sortOrder:1}\]; $mangular.isB2BCMGT = false; $mangular.isEpitopesModalImageMultiSizeEnabled = true;

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Conjugate

Unconjugated Unconjugated Unconjugated

Form

Liquid

Concentration

0.64 mg/mL

Purification

Affinity Chromatography

Storage buffer

PBS, pH 7.3, with 50% glycerol

Contains

0.02% sodium azide

Storage conditions

-20° C, Avoid Freeze/Thaw Cycles

Shipping conditions

Wet ice

RRID

AB_2804978

Product Specific Information

Immunogen sequence: KPTEKKDRVH HEPQLSDKVH NDAQSFDYDH DAFLGAEEAK TFDQLTPEES KERLGKIVSK IDGDKDGFVT VDELKDWIKF AQKRWIYEDV ERQWKGHDLN EDGLVSWEEY KNATYGYVLD DPDPDDGFNY KQMMVRDERR FKMADKDGDL IATKEEFTAF LHPEEYDYMK DIVVQETMED IDKNADGFID LEEYIGDMYS HDGNTDEPEW VKTEREQFVE FRDKNRDGKM DKEETKDWIL PSDYDHAEAE ARHLVYESDQ NKDGKLTKEE IVDKYDLFVG SQATDFGEAL VRHDEF; Positive Samples: H460, Rat liver; Cellular Location: Endoplasmic reticulum lumen, Melanosome, Sarcoplasmic reticulum lumen

Target Information

Caluminin is a 315 amino acid Ca2+-binding member of the CREC, EF-hand protein family. Calumenin is a secreted protein t hat contains six Ca2+-binding (EF-hand) motifs and is expressed in the lumen of the endoplasmic reticulum (ER) and Golgi apparatus. In the presence of Ca2+, Calumenin interacts with serum amyloid P component (SAP) and, together, they may play a role in the immunological defense system and participate in amyloidosis, the pathological formation of amyloid deposits in different types of tissues. Calumenin has an inhibitory effect on the vitamin K-dependent g-carboxylation system which converts vitamin K-dependent proteins to Gla-containing proteins. Calumenin may also be involved in the pathophysiology of thrombosis and/or wound healing by acting in an autocrine or paracrine manner.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.