Thermo Fisher Scientific RhoB Polyclonal Antibody
RhoB 단백질을 인식하는 Thermo Fisher Scientific의 Rabbit Polyclonal Antibody로, Mouse 및 Rat 시료에 반응. Western blot과 ELISA에 적합하며, 고순도 Affinity Chromatography로 정제됨. 세포막 및 핵 위치 단백질 검출에 유용.
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Thermo Fisher Scientific RhoB Polyclonal Antibody
Applications and Tested Dilution
| Application | Tested Dilution |
|---|---|
| Western Blot (WB) | 1:500–1:2,000 |
| ELISA | 1 µg/mL |
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Mouse, Rat |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | Recombinant fusion protein containing a sequence corresponding to amino acids 1–196 of human RhoB (NP_0040311) |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 1.26 mg/mL |
| Purification | Affinity Chromatography |
| Storage Buffer | PBS, pH 7.3, with 50% glycerol |
| Contains | 0.02% sodium azide |
| Storage Conditions | -20°C, Avoid Freeze/Thaw Cycles |
| Shipping Conditions | Wet ice |
| RRID | AB_2804975 |
Product Specific Information
- Immunogen sequence:
MAAIRKKLVV VGDGACGKTC LLIVFSKDEF PEVYVPTVFE NYVADIEVDG KQVELALWDT AGQEDYDRLR PLSYPDTDVI LMCFSVDSPD SLENIPEKWV PEVKHFCPNV PIILVANKKD LRSDEHVRTE LARMKQEPVR TDDGRAMAVR IQAYDYLECS AKTKEGVREV FETATRAALQ KRYGSQNGCI NCCKVL - Positive Samples: Mouse brain, Rat brain
- Cellular Location: Cell membrane, Cleavage furrow, Late endosome membrane, Lipid-anchor, Nucleus
Target Information
Rho-related GTP-binding protein (RhoB) mediates apoptosis in neoplastically transformed cells after DNA damage. While not essential for development, it affects cell adhesion and growth factor signaling in transformed cells. RhoB targets PKN1 to endosomes and is involved in trafficking of the EGF receptor from late endosomes to lysosomes. Also required for stability and nuclear trafficking of AKT1/AKT, promoting endothelial cell survival during vascular development. Serves as a tumor suppressor — deletion of RhoB causes tumor formation.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
제품 이미지
(이미지 파일: PA5-88525_RhoB_P62745-1_Rabbit.svg, PA5-88525_RhoB_P62745-1_Rabbit_PDP.jpeg)
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