Thermo Fisher Scientific beta-2 Microglobulin Polyclonal Antibody

Applications and Tested Dilutions

Product Specifications

Product Specific Information

Immunogen sequence:
IQRTPKIQVY SRHPAENGKS NFLNCYVSGF HPSDIEVDLL KNGERIEKVE HSDLSFSKDW SFYLLYYTEF TPTEKDEYAC RVNHVTLSQP KIVKWDRDM

Positive Samples: Jurkat, COS7, HeLa, K-562, Mouse liver, Mouse spleen

Target Information

Beta-2-microglobulin (B2M) is a 12–14 kDa protein that is a subunit of the major histocompatibility complex (MHC) class I.
Human beta-2 Microglobulin associated with HLA Class I antigens is expressed on many cell types including lymphocytes, thymocytes, monocytes, granulocytes, platelets, endothelial cells, and epithelial cells, but is absent on erythrocytes.
Beta-2 microglobulin is also found in free form in plasma. The amino acid sequence is homologous to the constant regions of immunoglobulin heavy and light chains, with a predominantly beta-pleated sheet structure.
The protein is ubiquitously expressed in the cytoplasm and is involved in antigen processing and presentation, TCR signaling, and downstream signaling in naive CD8+ cells.
The B2M gene is located on chromosome 15. Mutations in this gene can cause hypercatabolic hypoproteinemia.
Beta-2 microglobulin levels can be used to assess renal function in kidney transplant recipients and as a prognostic marker for HIV infection.

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For more information, visit www.P65Warnings.ca.gov.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.