Thermo Fisher Scientific beta-2 Microglobulin Polyclonal Antibody
Human, Mouse, Rat에 반응하는 Rabbit Polyclonal Antibody로, WB, IHC(P), ELISA에 사용 가능. Recombinant beta-2 Microglobulin(aa 21-119)을 면역원으로 제작. 액상형, 1.28 mg/mL, PBS/glycerol buffer에 보관. -20°C에서 보관하며, 연구용으로만 사용.
- 카탈로그번호
- PA588527
- 판매단위
- pk
카탈로그
1개 옵션 · 카탈로그 번호를 클릭하면 복사됩니다Thermo Fisher Scientific · Thermo Fisher Scientific beta-2 Microglobulin Polyclonal Antibody
Applications and Tested Dilutions
| Application | Tested Dilution | Publications |
|---|---|---|
| Western Blot (WB) | 1:500–1:1,000 | View 1 publication |
| Immunohistochemistry (Paraffin) (IHC (P)) | 1:50–1:200 | - |
| ELISA | 1 µg/mL | - |
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human, Mouse, Rat |
| Published Species | Not Applicable |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | Recombinant fusion protein containing a sequence corresponding to amino acids 21–119 of human beta-2 Microglobulin (NP_004039.1) |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 1.28 mg/mL |
| Purification | Affinity Chromatography |
| Storage Buffer | PBS, pH 7.3, with 50% glycerol |
| Contains | 0.01% thimerosal |
| Storage Conditions | -20°C, Avoid Freeze/Thaw Cycles |
| Shipping Conditions | Wet ice |
| RRID | AB_2804977 |
Product Specific Information
Immunogen sequence:
IQRTPKIQVY SRHPAENGKS NFLNCYVSGF HPSDIEVDLL KNGERIEKVE HSDLSFSKDW SFYLLYYTEF TPTEKDEYAC RVNHVTLSQP KIVKWDRDM
Positive Samples: Jurkat, COS7, HeLa, K-562, Mouse liver, Mouse spleen
Target Information
Beta-2-microglobulin (B2M) is a 12–14 kDa protein that is a subunit of the major histocompatibility complex (MHC) class I.
Human beta-2 Microglobulin associated with HLA Class I antigens is expressed on many cell types including lymphocytes, thymocytes, monocytes, granulocytes, platelets, endothelial cells, and epithelial cells, but is absent on erythrocytes.
Beta-2 microglobulin is also found in free form in plasma. The amino acid sequence is homologous to the constant regions of immunoglobulin heavy and light chains, with a predominantly beta-pleated sheet structure.
The protein is ubiquitously expressed in the cytoplasm and is involved in antigen processing and presentation, TCR signaling, and downstream signaling in naive CD8+ cells.
The B2M gene is located on chromosome 15. Mutations in this gene can cause hypercatabolic hypoproteinemia.
Beta-2 microglobulin levels can be used to assess renal function in kidney transplant recipients and as a prognostic marker for HIV infection.
⚠ WARNING: This product can expose you to chemicals including mercury, which is known to the State of California to cause birth defects or other reproductive harm.
For more information, visit www.P65Warnings.ca.gov.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
Thermo Fisher Scientific 상품 둘러보기
전체보기
문의
0개 · 배송·재고 문의는 실시간 상담이 빠릅니다아직 등록된 문의가 없어요.