Thermo Fisher Scientific Human BACE1 Synthetic Peptide
Human BACE1 합성 펩타이드로 Alzheimer 연구용. BACE1 항체 차단(Blocking Assay)에 사용 가능. 17개 아미노산으로 구성된 인간 BACE1 C-말단 부위 대응. 고순도 정제, 액상 형태, -20°C 보관. 연구용으로만 사용 가능.
- 판매단위
- pk
카탈로그
1개 옵션 · 카탈로그 번호를 클릭하면 복사됩니다Thermo Fisher Scientific · Thermo Fisher Scientific Human BACE1 Synthetic Peptide
Thermo Fisher Scientific Human BACE1 Synthetic Peptide
Applications
- Control (Ctrl): Assay-dependent
- Blocking Assay (BLOCK): Assay-dependent
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human |
| Class | Synthetic |
| Type | Peptide |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 200 µg/mL |
| Purification | Purified |
| Storage Buffer | PBS, pH 7.2, with 0.1% BSA |
| Contains | 0.02% sodium azide |
| Storage Conditions | -20°C |
Product Specific Information
This peptide corresponds to 17 amino acids near the carboxy terminus of human BACE.
PEP-0077 can be used as a blocking peptide with polyclonal antibody PA5-19952.
Target Information
BACE1 (beta-secretase) is a key enzyme involved in the production of amyloid beta-peptides (Abeta) found in extracellular amyloid plaques of Alzheimer’s disease (AD).
In some cases, early-onset familial AD can be attributed to a "Swedish" mutation in the amyloid precursor protein (APP), which enhances cleavage by BACE1.
Therapeutic approaches have focused on inhibiting BACE1 and other APP-cleaving enzymes such as gamma-secretase.
APP is first cleaved by beta-secretase, producing a soluble derivative and a membrane-anchored 99-amino acid fragment (C99).
C99 serves as a substrate for gamma-secretase, generating the 4 kDa amyloid-beta peptide deposited in AD brains.
BACE1 (Asp2) was identified as a novel transmembrane aspartic protease and colocalizes with APP.
Usage Notice
For Research Use Only. Not for use in diagnostic procedures.
Not for resale without express authorization.
Thermo Fisher Scientific 상품 둘러보기
전체보기
문의
0개 · 배송·재고 문의는 실시간 상담이 빠릅니다아직 등록된 문의가 없어요.