Thermo Fisher Scientific Human BACE1 Synthetic Peptide

Thermo Fisher Scientific Human BACE1 Synthetic Peptide

Applications

• Control (Ctrl): Assay-dependent
• Blocking Assay (BLOCK): Assay-dependent

Product Specifications

Product Specific Information

This peptide corresponds to 17 amino acids near the carboxy terminus of human BACE.
PEP-0077 can be used as a blocking peptide with polyclonal antibody PA5-19952.

Target Information

BACE1 (beta-secretase) is a key enzyme involved in the production of amyloid beta-peptides (Abeta) found in extracellular amyloid plaques of Alzheimer’s disease (AD).
In some cases, early-onset familial AD can be attributed to a "Swedish" mutation in the amyloid precursor protein (APP), which enhances cleavage by BACE1.
Therapeutic approaches have focused on inhibiting BACE1 and other APP-cleaving enzymes such as gamma-secretase.
APP is first cleaved by beta-secretase, producing a soluble derivative and a membrane-anchored 99-amino acid fragment (C99).
C99 serves as a substrate for gamma-secretase, generating the 4 kDa amyloid-beta peptide deposited in AD brains.
BACE1 (Asp2) was identified as a novel transmembrane aspartic protease and colocalizes with APP.

Usage Notice

For Research Use Only. Not for use in diagnostic procedures.
Not for resale without express authorization.