Thermo Fisher Scientific Human BACE1 Synthetic Peptide
Human BACE1 합성 펩타이드로 Alzheimer 연구용. BACE1 항체 차단(Blocking Assay)에 사용 가능. 17개 아미노산으로 구성된 인간 BACE1 C-말단 부위 대응. 고순도 정제, 액상 형태, -20°C 보관. 연구용으로만 사용 가능.
- 카탈로그번호
- PEP0077
- 판매단위
- pk
카탈로그
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Thermo Fisher Scientific Human BACE1 Synthetic Peptide
Applications
- Control (Ctrl): Assay-dependent
- Blocking Assay (BLOCK): Assay-dependent
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human |
| Class | Synthetic |
| Type | Peptide |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 200 µg/mL |
| Purification | Purified |
| Storage Buffer | PBS, pH 7.2, with 0.1% BSA |
| Contains | 0.02% sodium azide |
| Storage Conditions | -20°C |
Product Specific Information
This peptide corresponds to 17 amino acids near the carboxy terminus of human BACE.
PEP-0077 can be used as a blocking peptide with polyclonal antibody PA5-19952.
Target Information
BACE1 (beta-secretase) is a key enzyme involved in the production of amyloid beta-peptides (Abeta) found in extracellular amyloid plaques of Alzheimer’s disease (AD).
In some cases, early-onset familial AD can be attributed to a "Swedish" mutation in the amyloid precursor protein (APP), which enhances cleavage by BACE1.
Therapeutic approaches have focused on inhibiting BACE1 and other APP-cleaving enzymes such as gamma-secretase.
APP is first cleaved by beta-secretase, producing a soluble derivative and a membrane-anchored 99-amino acid fragment (C99).
C99 serves as a substrate for gamma-secretase, generating the 4 kDa amyloid-beta peptide deposited in AD brains.
BACE1 (Asp2) was identified as a novel transmembrane aspartic protease and colocalizes with APP.
Usage Notice
For Research Use Only. Not for use in diagnostic procedures.
Not for resale without express authorization.
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