Thermo Fisher Scientific TWIST1 Recombinant Rabbit Monoclonal Antibody (BLR156J)
TWIST1 단백질을 인식하는 재조합 토끼 단일클론 항체로, Western blot, ICC/IF, IP 등 다양한 분석에 적합합니다. 인간 시료 반응성이 있으며, HEK293F 발현 시스템에서 생산된 고순도 항체입니다. 연구용으로만 사용됩니다.
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Applications
- Western Blot (WB): Assay-dependent
- Immunocytochemistry (ICC/IF): Assay-dependent
- Immunoprecipitation (IP): Assay-dependent
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human |
| Host / Isotype | Rabbit / IgG |
| Expression System | HEK293F |
| Class | Recombinant Monoclonal |
| Type | Antibody |
| Clone | BLR156J |
| Immunogen | Peptide representing a region between residue 1 and 50 of Human Twist-related protein 1 |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 1 mg/mL |
| Purification | Purified |
| Storage Buffer | BBS, pH 8.2 |
| Contains | 0.09% sodium azide |
| Storage Conditions | 4°C |
| Shipping Conditions | Ambient (domestic); Wet ice (international) |
Target Information
TWIST1 acts as a transcriptional regulator. It inhibits myogenesis by sequestering E proteins, inhibiting trans-activation by MEF2, and inhibiting DNA-binding by MYOD1 through physical interaction. TWIST1 also represses proinflammatory cytokines such as TNFA and IL1B. It regulates cranial suture patterning and fusion and gene expression depending on dimer composition. Mutations in the gene are implicated in Saethre-Chotzen syndrome, characterized by coronal synostosis, brachycephaly, low front hairline, facial asymmetry, hypertelorism, broad halluces, and clinodactyly.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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