Thermo Fisher Scientific CD81 Monoclonal Antibody (M38)
CD81 단백질을 인식하는 Mouse monoclonal antibody (clone M38). Western blot, IHC, ICC, Flow cytometry, IP 등에 사용 가능. Human, Cat, Rabbit 반응성. 비결합형, Protein A 정제, PBS buffer에 보관. 4°C 보관, 동결 금지.
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Applications and Tested Dilutions
| Application | Tested Dilution | Publications |
|---|---|---|
| Western Blot (WB) | 1–2 µg/mL | 3 publications |
| Immunohistochemistry (Paraffin) (IHC (P)) | Assay-dependent | - |
| Immunocytochemistry (ICC/IF) | Assay-dependent | 1 publication |
| Flow Cytometry (Flow) | 1 µg/mL | - |
| Immunoprecipitation (IP) | Assay-dependent | - |
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Cat, Human, Rabbit |
| Published Species | Human |
| Host / Isotype | Mouse / IgG1 |
| Class | Monoclonal |
| Type | Antibody |
| Clone | M38 |
| Immunogen | MOLT-4 (human T-ALL cell line) |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 1 mg/mL |
| Purification | Protein A |
| Storage Buffer | PBS, pH 7.4 |
| Contains | 15 mM sodium azide |
| Storage Conditions | 4°C, do not freeze |
| Shipping Conditions | Ambient (domestic); Wet ice (international) |
| RRID | AB_11155175 |
Available Conjugated Formats
- Alexa Fluor 488 (MA5-44132)
- FITC (A15753)
- PE (MA1-10292)
- Request custom conjugation
Product Specific Information
This antibody reacts with an extracellular epitope of CD81, a 25 kDa member of the tetraspanin family expressed on the majority of cells.
Western Blot: Use under non-reducing conditions.
Target Information
CD81 (TAPA-1, target of anti-proliferative antibody-1) is a member of the tetraspanin family expressed on nearly all nucleated cells, especially germinal center B cells.
It forms complexes with other tetraspanins, integrins, coreceptors, and MHC molecules, influencing adhesion, morphology, activation, proliferation, and differentiation of B and T cells.
In muscle cells, CD81 promotes cell fusion and myotube maintenance. It also serves as a receptor for the hepatitis C virus.
CD81 is a cell surface glycoprotein associated with integrins and may act as a tumor suppressor candidate gene.
Antibodies to CD81 exhibit anti-proliferative effects on lymphoid cell lines, particularly large cell lymphomas.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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