Thermo Fisher Scientific CD80 Monoclonal Antibody (MEM-233), PE

Applications

Flow Cytometry (Flow)

• Tested Dilution: 20 µL / 1×10⁶ cells
• Publications: View 6 publications

Miscellaneous PubMed (Misc)

• Tested Dilution: –
• Publications: View 2 publications

Product Specifications

Additional Formats

• Unconjugated
• Alexa Fluor 700
• APC
• FITC
• PerCP
• Request custom conjugation

Product Specific Information

This antibody reacts with an extracellular epitope of CD80 (B7-1), a 60 kDa single-chain type I glycoprotein of the immunoglobulin supergene family. It is expressed on professional antigen-presenting cells such as dendritic cells, macrophages, or activated B lymphocytes.

Target Information

CD80 (B7-1) and CD86 (B7-2) are ligands of the T cell costimulatory molecule CD28 and the inhibitory receptor CTLA-4 (CD152). Both are expressed on professional antigen-presenting cells and are essential for T cell activation. CD80 is rapidly induced on activated B cells, EBV-transformed B cell lines, Burkitt’s lymphoma cell lines, follicular B lymphoma cells, T cells, and monocytes.
The B-lymphocyte activation antigen B7-1 provides regulatory signals for T lymphocytes by binding to CD28 and CTLA4.
Diseases associated with CD80 dysfunction include gallbladder squamous cell carcinoma and myocarditis.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.

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