Thermo Fisher Scientific CD80 Monoclonal Antibody (MEM-233), PE
PE 형광으로 표지된 CD80 (B7-1) 단클론 항체로 인간 세포에 반응합니다. Flow Cytometry에 적합하며, 면역세포 활성화 연구에 활용됩니다. 액상 형태로 4°C 암소 보관하며 동결 금지. 연구용으로만 사용 가능합니다.
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Applications
Flow Cytometry (Flow)
- Tested Dilution: 20 µL / 1×10⁶ cells
- Publications: View 6 publications
Miscellaneous PubMed (Misc)
- Tested Dilution: –
- Publications: View 2 publications
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human |
| Published Species | Human |
| Host / Isotype | Mouse / IgG1 |
| Class | Monoclonal |
| Type | Antibody |
| Clone | MEM-233 |
| Immunogen | Extracellular domain of human CD80 fused to human IgG1 (Fc) |
| Conjugate | PE |
| Excitation / Emission Max | 565 / 576 nm |
| Form | Liquid |
| Purification | Size-exclusion chromatography |
| Storage Buffer | PBS, pH 7.4, with 0.2% BSA |
| Contains | 15 mM sodium azide |
| Storage Conditions | 4°C, store in dark, DO NOT FREEZE |
| Shipping Conditions | Ambient (domestic); Wet ice (international) |
| RRID | AB_11157666 |
Additional Formats
- Unconjugated
- Alexa Fluor 700
- APC
- FITC
- PerCP
- Request custom conjugation
Product Specific Information
This antibody reacts with an extracellular epitope of CD80 (B7-1), a 60 kDa single-chain type I glycoprotein of the immunoglobulin supergene family. It is expressed on professional antigen-presenting cells such as dendritic cells, macrophages, or activated B lymphocytes.
Target Information
CD80 (B7-1) and CD86 (B7-2) are ligands of the T cell costimulatory molecule CD28 and the inhibitory receptor CTLA-4 (CD152). Both are expressed on professional antigen-presenting cells and are essential for T cell activation. CD80 is rapidly induced on activated B cells, EBV-transformed B cell lines, Burkitt’s lymphoma cell lines, follicular B lymphoma cells, T cells, and monocytes.
The B-lymphocyte activation antigen B7-1 provides regulatory signals for T lymphocytes by binding to CD28 and CTLA4.
Diseases associated with CD80 dysfunction include gallbladder squamous cell carcinoma and myocarditis.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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