Thermo Fisher Scientific EphA2 Recombinant Human Monoclonal Antibody (1C1)
인간 EphA2 단백질을 인식하는 재조합 단일클론 항체로 다양한 면역분석(WB, ICC/IF, Flow, ELISA, Functional Assay)에 사용 가능. HEK293 세포에서 발현된 인간 IgG1 형식이며, 높은 특이성과 친화도를 가짐. 단기 4°C, 장기 -20°C 보관 권장.
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Applications and Tested Dilution
| Application | Tested Dilution |
|---|---|
| Western Blot (WB) | Assay-dependent |
| Immunocytochemistry (ICC/IF) | Assay-dependent |
| Flow Cytometry (Flow) | Assay-dependent |
| ELISA | Assay-dependent |
| Functional Assay | Assay-dependent |
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human |
| Host / Isotype | Human / IgG1, kappa |
| Expression System | HEK293 cells |
| Class | Recombinant Monoclonal |
| Type | Antibody |
| Clone | 1C1 |
| Immunogen | 1C1 was isolated after screening of a non-immunized human Fab phage library. Selection was based on the ability to bind soluble human recombinant EphA2 (residues 183–510). The Fab was subsequently converted to full-length human IgG1. |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 1 mg/mL |
| Purification | Protein A |
| Storage Buffer | PBS |
| Contains | 0.02% ProClin 300 |
| Storage Conditions | Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles. |
| Shipping Conditions | Wet ice |
| RRID | AB_3074397 |
Product Specific Information
Specificity:
1C1 binds specifically to the amino-terminal LBD (ligand-binding domain) region of the EphA2 ectodomain (IgG1 KD ~0.8 nM; Fab KD ~140 nM) and not to other related human Eph receptors such as EphA1, EphA3, and EphA4, or any EphB receptor family members.
Target Information
EPHA2 belongs to the ephrin receptor subfamily of the protein tyrosine kinase family. EPH and EPH-related receptors are involved in developmental events, particularly in the nervous system. EPHA2 is overexpressed in many types of human cancers. The tyrosine kinase group regulates cell-cell interactions such as differentiation, adhesion, motility, and death. There are approximately 90 TK genes sequenced, including 58 receptor TKs (EGFR, EPH, FGFR, PDGFR, TRK, VEGFR families) and 32 cytosolic TKs (ABL, FAK, JAK, SRC families).
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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