Thermo Fisher Scientific CD8 Monoclonal Antibody (3B5)
Thermo Fisher Scientific의 CD8 Monoclonal Antibody (Clone 3B5)은 인간 CD8 항원을 표적하는 Mouse IgG2a 형 단일클론 항체입니다. Flow Cytometry, ICC/IF, IP, ChIP 등 다양한 응용에 사용 가능하며, 비결합형 액상 형태로 제공됩니다. PBS buffer에 0.1% sodium azide 포함, 4°C 암소 보관 권장.
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Applications and Tested Dilution
| Application | Tested Dilution | Publications |
|---|---|---|
| Immunocytochemistry (ICC/IF) | - | View 1 publication |
| Flow Cytometry (Flow) | Assay-dependent | View 113 publications |
| Immunoprecipitation (IP) | - | View 1 publication |
| ChIP assay (ChIP) | - | View 1 publication |
| Miscellaneous PubMed (Misc) | - | View 24 publications |
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human |
| Published Species | Fruit fly, Human, Mouse, Non-human primate, Rhesus monkey |
| Host / Isotype | Mouse / IgG2a |
| Class | Monoclonal |
| Type | Antibody |
| Clone | 3B5 |
| Immunogen | Human CD8 |
| Conjugate | Unconjugated |
| Form | Liquid |
| Purification | Purified |
| Storage Buffer | PBS |
| Contains | 0.1% sodium azide |
| Storage Conditions | 4°C, store in dark |
| Shipping Conditions | Ambient (domestic); Wet ice (international) |
| RRID | AB_10372813 |
Available Conjugated Formats
- Alexa Fluor 405
- Alexa Fluor 647
- Alexa Fluor 700
- APC
- APC-Alexa Fluor 750
- FITC
- Pacific Blue
- Pacific Orange
- PE
- PE-Alexa Fluor 610
- PE-Cyanine5.5
- PE-Cyanine7
- PE-Texas Red
- PerCP
- Qdot 605
- Qdot 655
- Qdot 705
- Qdot 800
- TRI-COLOR
- Request custom conjugation available
Target Information
Cluster of differentiation 8 (CD8) is a type I transmembrane glycoprotein of the immunoglobulin receptor family. It plays a critical role in signal transduction, T cell differentiation, and activation. CD8 is predominantly expressed on T cells as a disulfide-linked heterodimer of CD8α and CD8β, functioning as a co-receptor with T cell receptor (TCR) for MHC class I molecules. In contrast, CD4 acts as a co-receptor for MHC class II molecules.
CD8α is essential for binding to MHC-I and is also expressed on subsets of T cells, NK cells, monocytes, and dendritic cells as CD8α homodimers. Interaction of MHC-I/peptide complexes with CD8 triggers recruitment of Lck kinase, leading to lymphokine production, motility, and cytotoxic T lymphocyte (CTL) activation. Activated CTLs are key in pathogen and tumor cell clearance. Differentiation of naive CD8+ T cells into CTLs is enhanced by IL-2, IL-12, and TGF-β1.
Analyte Specific Reagent
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배송/결제/교환/반품 안내
배송 정보
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