Thermo Fisher Scientific NRXN3 Polyclonal Antibody

Applications

Product Specifications

Product Specific Information

Antibody detects endogenous levels of total NRXN3.

Target Information

Neurexins comprise a family of neuronal cell surface proteins, including neurexin I (NRXN1), neurexin II (NRXN2), neurexin III (NRXN3), and Caspr (neurexin IV).
Neurexins I–III are expressed as α and β isoforms.

• α-isoforms: Contain three cassettes with two LNS (Laminin A, Neurexins, Sex hormone-binding) domains separated by EGF domains, followed by a transmembrane region and a 55 amino acid cytoplasmic C-terminal. These bind to neurexophilins and α-latrotoxin.
• β-isoforms: Contain one LNS-domain, bind to neuroligins, and are involved in synapse formation and remodeling.
  Caspr (Contactin-Associated Protein 1, also known as Paranodin in mouse) has an extracellular domain similar to other neurexins and binds to Contactin. Caspr and Caspr2 (a mammalian homolog of Drosophila Neurexin IV) define distinct subdomains in myelinated axons: Caspr at paranodal junctions, Caspr2 with Shaker-like K⁺ channels in the juxtaparanodal region. Caspr may play a role in neuron–glia communication during development.

For Research Use Only.
Not for use in diagnostic procedures. Not for resale without express authorization.