Thermo Fisher Scientific ATXN7L2 Polyclonal Antibody
Rabbit polyclonal antibody against human ATXN7L2 for ICC/IF applications. Recombinant protein immunogen-based, antigen affinity purified, and unconjugated. Provided in liquid form with PBS/glycerol buffer for research use only.
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Thermo Fisher Scientific ATXN7L2 Polyclonal Antibody
Applications and Tested Dilution
- Immunocytochemistry (ICC/IF): 0.25–2 µg/mL
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | Recombinant Human ATXN7L2. Recombinant protein control fragment (Product #RP-106585) |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 0.2 mg/mL |
| Purification | Antigen affinity chromatography |
| Storage Buffer | PBS, pH 7.2, with 40% glycerol |
| Contains | 0.02% sodium azide |
| Storage Conditions | Store at 4°C short term. For long term, store at -20°C, avoiding freeze/thaw cycles. |
| Shipping Conditions | Wet ice |
| RRID | AB_2663561 |
Product Specific Information
Immunogen sequence:
KTKTALSMGLN GTMGPRVKRA GPLDCRGSPH QLPTPVKASQ LENRGAAGHP AKALPTNCLS EEEVAKKRKN LATYCRPVKA KHCQAGAPAD V
Highest antigen sequence identity to orthologs:
- Mouse: 87%
- Rat: 86%
Target Information
SCA7 is an autosomal dominant neurodegenerative disorder characterized by ataxia and selective neuronal cell loss caused by the expansion of a translated CAG repeat encoding a polyglutamine tract in ataxin-7, the SCA7 gene product.
Ataxin-7 is a nuclear protein expressed within neurons, with variable subcellular localization depending on neuronal subtype. Polyglutamine-expanded ataxin-7 may exert pathogenic effects by altering nuclear structure or disrupting nucleolar function.
ATXN7L2 (Ataxin-7-like protein 2) is a 722 amino acid protein containing a conserved SCA7 domain. The gene encoding ATXN7L2 maps to human chromosome 1, which spans about 260 million base pairs and constitutes approximately 8% of the human genome.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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