Thermo Fisher Scientific ATMIN Polyclonal Antibody
Rabbit polyclonal antibody against human ATMIN protein. Validated for ICC/IF applications with high specificity. Antigen affinity-purified and supplied in PBS buffer with glycerol. Suitable for DNA damage and transcription regulation studies.
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Applications
- Immunocytochemistry (ICC/IF): 0.25–2 µg/mL
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | Recombinant Human ATMIN. Recombinant protein control fragment (Product #RP-106587) |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 0.2 mg/mL |
| Purification | Antigen affinity chromatography |
| Storage Buffer | PBS, pH 7.2, with 40% glycerol |
| Contains | 0.02% sodium azide |
| Storage Conditions | Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles. |
| Shipping Conditions | Wet ice |
| RRID | AB_2662101 |
Product Specific Information
Immunogen sequence:
SVSELSRAVRT NILCTVRGCG KILPNSPALN MHLVKSHRLQ DGIVNPTIRK DLKTGPKFYC CPIEGCPRGP ERPFSQFSLV KQHFMKMHAE KKHKC
Highest antigen sequence identity to the following orthologs:
- Mouse: 95%
- Rat: 95%
Target Information
The ATM/ATR-substrate CHK2-interacting zinc finger protein (ATMIN), also known as ASCIZ, forms DNA damage-induced nuclear foci containing the DNA repair protein Rad51. ATMIN is also involved in embryonic development, as its absence causes late-embryonic lethality in mice with organ development defects. It activates transcription of DYNLL1, a light chain of the dynein motor complex and regulator of protein dimerization. DYNLL1 can bind to and inhibit the transcription activation domain of ATMIN, forming a feedback loop for DYNLL1 expression.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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