Thermo Fisher Scientific AHR Polyclonal Antibody
AHR 단백질을 인식하는 Thermo Fisher Scientific의 Goat Polyclonal Antibody. IHC, ICC/IF, Flow Cytometry 등에 사용 가능하며, Human 반응성. 0.5 mg/mL 농도의 액상 형태로 제공되며, -20°C 보관.
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Applications
| Application | Tested Dilution |
|---|---|
| Immunohistochemistry (Paraffin) (IHC (P)) | 2–4 µg/mL |
| Immunocytochemistry (ICC/IF) | 10 µg/mL |
| Flow Cytometry (Flow) | 10 µg/mL |
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human |
| Host / Isotype | Goat / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | Peptide with sequence C-PENQKHGLNPQSA |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 0.5 mg/mL |
| Purification | Ammonium sulfate precipitation |
| Storage Buffer | TBS, pH 7.3, with 0.5% BSA |
| Contains | 0.02% sodium azide |
| Storage Conditions | -20°C, Avoid Freeze/Thaw Cycles |
| Shipping Conditions | Wet ice |
| RRID | AB_2933110 |
Product Specific Information
This antibody is tested in Peptide ELISA: antibody detection limit dilution 1:1,000.
Target Information
AHR (Ah Receptor) belongs to a family of proteins comprised of its dimerization partner ARNT (HIF-1 Beta) and the Drosophila proteins PER and SIM. AHR contains an N-terminal PAS domain (~200 amino acids) and is found in various tissues. It binds to specific DNA enhancer sequences to initiate transcription of the cytochrome P-450 (CYPIA1) gene.
AHR encodes a ligand-activated transcription factor regulating biological responses to planar aromatic hydrocarbons and xenobiotic-metabolizing enzymes such as cytochrome P450. Known ligands include polycyclic and halogenated aromatic compounds such as 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD).
In non-ligand activated cells, AHR is complexed with HSP90 in the cytoplasm. Upon ligand binding, AHR transforms into a nuclear DNA-binding form, dissociates from HSP90, and forms a heterodimer with ARNT.
Diseases associated with AHR include eosinophilic fasciitis and seborrheic dermatitis.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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