Thermo Fisher Scientific SCN9A Monoclonal Antibody (N68/6)
SCN9A 단백질(Nav1.7)을 특이적으로 인식하는 Mouse monoclonal antibody. Western blot, IHC, ICC, IP 등 다양한 응용에 적합. Human, Mouse, Rat, Hamster 반응성. Protein G 정제, PBS/glycerol buffer, -20°C 보관.
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Applications and Tested Dilutions
| Application | Tested Dilution |
|---|---|
| Western Blot (WB) | 1:1,000 |
| Immunohistochemistry (Paraffin) (IHC-P) | 1:50 |
| Immunohistochemistry (Frozen) (IHC-F) | 1:1,000 |
| Immunocytochemistry (ICC/IF) | 1:100 |
| Immunoprecipitation (IP) | Assay-dependent |
| Antibody Microarray (AM) | Assay-dependent |
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Hamster, Human, Mouse, Rat |
| Host / Isotype | Mouse / IgG1 |
| Class | Monoclonal |
| Type | Antibody |
| Clone | N68/6 |
| Immunogen | Fusion protein amino acids 1751–1946 (C-terminus) of human Nav1.7 |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 1 mg/mL |
| Purification | Protein G |
| Storage Buffer | PBS, pH 7.4, with 50% glycerol |
| Contains | 0.09% sodium azide |
| Storage Conditions | -20°C |
| Shipping Conditions | Wet ice |
| RRID | AB_2735356 |
Additional Formats
Product Specific Information
1 µg/mL of MA5-27664 was sufficient for detection of Nav1.7 in 10 µg of HEK-293 cell lysate transiently expressing Nav1.7 by colorimetric immunoblot analysis using Goat anti-mouse IgG:HRP as the secondary antibody. Detects approximately 230 kDa. No cross-reactivity against other Nav channels.
Target Information
Epithelial sodium channels (ENaC) are amiloride-sensitive members of the Degenerin/epithelial sodium channel (Deg/ENaC) superfamily of ion channels. These channels share structural similarity with two short intracellular termini, two transmembrane segments, and a large extracellular loop with conserved cysteine-rich regions. ENaC isoforms (α, β, γ) are expressed in kidney, lung, and colon, playing key roles in sodium and fluid balance. They also mediate aldosterone-dependent sodium reabsorption in the distal nephron, regulating blood pressure. Mutations in ENaC subunits can cause hypertension (Liddle’s syndrome) or pseudohypoaldosteronism (PHA-1).
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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