Thermo Fisher Scientific SCN10A Monoclonal Antibody (S134)
SCN10A 단백질을 인식하는 S134 클론의 단클론 항체로, 인간, 마우스, 비인간 영장류 및 랫드 시료에 반응합니다. Western blot, IHC, ICC/IF, AM 등 다양한 응용에 사용 가능합니다. 단백질 G로 정제된 액상 형태로, 1 mg/mL 농도이며 -20°C에서 보관합니다.
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- pk
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Applications and Tested Dilutions
| Application | Tested Dilution |
|---|---|
| Western Blot (WB) | 1:1,000 |
| Immunohistochemistry (Paraffin) (IHC (P)) | 1:1,000 |
| Immunocytochemistry (ICC/IF) | 1:100 |
| Antibody Microarray (AM) | Assay-dependent |
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human, Mouse, Non-human primate, Rat |
| Host / Isotype | Mouse / IgG2a |
| Class | Monoclonal |
| Type | Antibody |
| Clone | S134 |
| Immunogen | Fusion protein amino acids 1724–1956 of rat Nav1.8 |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 1 mg/mL |
| Purification | Protein G |
| Storage Buffer | PBS, pH 7.4, with 50% glycerol |
| Contains | 0.09% sodium azide |
| Storage Conditions | -20°C |
| Shipping Conditions | Wet ice |
| RRID | AB_2735353 |
Additional Conjugate Formats
Product Specific Information
- 1 µg/mL of MA5-27663 was sufficient for detection of Nav1.8 in 10 µg of COS cell lysate transiently expressing Nav1.8 by colorimetric immunoblot analysis using Goat anti-mouse IgG:HRP as the secondary antibody.
- Detects approximately 220 kDa.
- No cross-reactivity against other Nav channels.
Target Information
Scn10a is a tetrodotoxin-resistant voltage-gated sodium channel alpha subunit. It mediates voltage-dependent sodium ion permeability of excitable membranes and plays a role in neuropathic pain mechanisms. Members of the Degenerin/epithelial sodium channel (Deg/ENaC) superfamily share structural similarities, including two short intracellular termini, two transmembrane segments, and a large extracellular loop with a conserved cysteine-rich region.
Epithelial sodium channels (ENaC) in kidney, lung, and colon are essential for sodium and fluid balance and are regulated by aldosterone and CFTR chloride channels. Mutations in ENaC subunits can lead to conditions such as Liddle’s syndrome and pseudohypoaldosteronism (PHA-1). Diseases associated with SCN10A include Episodic Pain Syndrome, Familial, 2, and Sodium Channelopathy-Related Small Fiber Neuropathy.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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