Thermo Fisher Scientific Phospho-GABBR1 (Ser923) Polyclonal Antibody
GABBR1 단백질의 Ser923 인산화 부위를 인식하는 Rabbit Polyclonal Antibody. 인간, 마우스, 랫트 반응성. WB, IHC, ICC, ELISA 등 다양한 응용 가능. 고순도 Protein A 정제, 액상 형태로 안정적 보관 가능.
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Thermo Fisher Scientific Phospho-GABBR1 (Ser923) Polyclonal Antibody
Applications and Tested Dilution
| Application | Tested Dilution |
|---|---|
| Western Blot (WB) | Assay-dependent |
| Immunohistochemistry (Paraffin) (IHC (P)) | Assay-dependent |
| Immunohistochemistry (Frozen) (IHC (F)) | 1:100–1:500 |
| Immunocytochemistry (ICC/IF) | 1:50–1:200 |
| ELISA | 1:500–1:1,000 |
Product Specifications
| Item | Description |
|---|---|
| Species Reactivity | Human, Mouse, Rat |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | KLH-conjugated synthetic phosphopeptide derived from mouse GABBR1 around the phosphorylation site of Ser923 |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 1 mg/mL |
| Purification | Protein A |
| Storage Buffer | 0.01M TBS, pH 7.4, with 50% glycerol, 1% BSA |
| Contains | 0.02% ProClin 300 |
| Storage Conditions | -20°C |
| Shipping Conditions | Ambient (domestic); Wet ice (international) |
Target Information
Receptor for GABA. The activity of this receptor is mediated by G-proteins that inhibit adenylyl cyclase activity, stimulate phospholipase A2, activate potassium channels, inactivate voltage-dependent calcium channels, and modulate inositol phospholipids hydrolysis. Plays a critical role in fine-tuning inhibitory synaptic transmission.
Pre-synaptic GABA-B receptors inhibit neurotransmitter release by down-regulating high-voltage activated calcium channels, whereas postsynaptic GABA-B receptors decrease neuronal excitability by activating inwardly rectifying potassium (Kir) conductance underlying late inhibitory postsynaptic potentials.
Implications include synaptic inhibition, hippocampal long-term potentiation, slow wave sleep, muscle relaxation, and antinociception.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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