Thermo Fisher Scientific Phospho-GAB1 (Tyr659) Polyclonal Antibody
Phospho-GAB1 (Tyr659) 폴리클로날 항체로, 인간·마우스·랫트 시료에서 GAB1 Tyr659 인산화 단백질 검출에 적합합니다. Western blot과 IHC(P)에서 사용 가능하며, 고순도(>95%) 항원 친화 크로마토그래피 정제 제품입니다. 연구용으로만 사용됩니다.
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Applications and Tested Dilutions
| Application | Tested Dilution |
|---|---|
| Western Blot (WB) | 1:500–1:1,000 |
| Immunohistochemistry (Paraffin) (IHC (P)) | 1:50–1:200 |
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human, Mouse, Rat |
| Host/Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | Synthetic phosphopeptide derived from human Gab1 around the phosphorylation site of Tyrosine 659 |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 1 mg/mL |
| Purification | Antigen affinity chromatography |
| Storage buffer | PBS, pH 7.2 |
| Contains | 0.05% sodium azide |
| Storage conditions | Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles. |
| Shipping conditions | Ambient (domestic); Wet ice (international) |
| RRID | AB_2553745 |
Product Specific Information
- Detects endogenous protein at molecular weights of 76 and 110 kDa.
- Purity: >95% by SDS-PAGE.
Target Information
Gab1 is a 115 kDa multiple docking protein that plays an essential role in cellular growth, transformation, and apoptosis. It can be phosphorylated by multiple receptor tyrosine kinases (RTKs) such as:
- Insulin receptor (IR)
- Platelet-derived growth factor receptor beta (PDGFRβ)
- Hepatocyte growth factor/scatter factor receptor (HGFR/SFR or c-Met)
- Epidermal growth factor receptor (EGFR)
Gab1 is tyrosine phosphorylated on at least 16 sites, serving as binding sites for PI3K, Grb2, PLCγ1, Nck, and SHP2.
Phosphorylation on tyrosines 627 and 659 is critical for SHP2 binding and activation of the ERK/MAPK pathway in response to EGF.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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