Thermo Fisher Scientific AHR Polyclonal Antibody
AHR 단백질을 인식하는 Thermo Fisher Scientific의 goat polyclonal 항체로, IHC(P), ICC/IF, Gel Shift에 적합. 인간, 생쥐, 랫트 반응성. 액상형, 보존제 없음, -20°C 보관. 연구용으로만 사용.
- 카탈로그번호
- PA146110
- 판매단위
- pk
카탈로그
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Applications
| Application | Tested Dilution | Publications |
|---|---|---|
| Immunohistochemistry (Paraffin) (IHC (P)) | 1:100–1:200 | - |
| Immunocytochemistry (ICC/IF) | 1:100 | - |
| Gel Shift (GS) | 1:100 | View 1 publication |
Product Specifications
| Specification | Description |
|---|---|
| Species Reactivity | Human, Mouse, Rat |
| Published Species | Rat |
| Host / Isotype | Goat / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | N-terminal sequence of Aryl hydrocarbon Receptor purified from C57BL/6J mice |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | Not Determined |
| Storage Buffer | Whole serum |
| Contains | No preservative |
| Storage Conditions | -20°C, Avoid Freeze/Thaw Cycles |
| Shipping Conditions | Ambient (domestic); Wet ice (international) |
| RRID | AB_2223951 |
Product Specific Information
Suggested positive control: antigen standard for AHR (transient overexpression lysate).
This antibody is not recommended for Western Blot applications.
Target Information
AHR (Ah Receptor) belongs to a family of proteins that includes its dimerization partner ARNT (HIF-1 Beta) and the Drosophila proteins PER and SIM.
AHR contains an N-terminal sequence of approximately 200 amino acids termed the PAS domain. It binds to a specific DNA enhancer sequence and initiates transcription of the mRNA for the cytochrome P-450 (CYPIA1) gene.
AHR encodes a ligand-activated transcription factor regulating biological responses to planar aromatic hydrocarbons, including xenobiotic-metabolizing enzymes such as cytochrome P450.
Known ligands include polycyclic and halogenated aromatic compounds (e.g., TCDD).
In non-ligand activated cells, AHR is complexed with HSP90 in the cytoplasm. Upon agonist binding, AHR transforms into a nuclear DNA-binding form, forming a heterodimer with ARNT.
Diseases associated with AHR include eosinophilic fasciitis and seborrheic dermatitis.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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