Thermo Fisher Scientific Phospho-Survivin (Thr34) Polyclonal Antibody

Applications and Tested Dilutions

Product Specifications

Product Specific Information

The target sequence has 100% sequence homology with feline and primate, and 94% sequence homology with canine, porcine, and bovine.

Target Information

Survivin (IAP4) is the smallest member of the Inhibitors of Apoptosis Protein (IAP) gene family.
IAPs are involved in multiple cellular processes such as signaling, division, and metabolism, and show differential expression in most human cancers but not in normal tissues. Survivin contains a single BIR domain and lacks a C-terminal RING finger domain.

Gene expression is high during fetal development and in most tumors, but low in adult tissues. It is expressed in the G2/M phase of the cell cycle and associates with mitotic spindle microtubules in a regulated manner. Disruption of this interaction increases caspase-3 activity and apoptosis during mitosis.

Survivin is also expressed in adult rat brain tissues after traumatic injury, co-localizing with NeuN and PCNA, suggesting a role in neural cell proliferation. Multiple transcript variants exist, with overexpression in cancer potentially bypassing apoptotic checkpoints and promoting abnormal mitosis.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.