Thermo Fisher Scientific Phospho-WRN (Ser1141) Polyclonal Antibody
인간 WRN 단백질의 Ser1141 인산화 부위를 인식하는 폴리클로날 항체입니다. Western blot에 최적화되어 있으며, 항원 친화 크로마토그래피로 정제되었습니다. 액상 형태로 제공되며, -20°C에서 보관합니다. 연구용으로만 사용 가능합니다.
- 카탈로그번호
- PA538932
- 판매단위
- pk
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Thermo Fisher Scientific Phospho-WRN (Ser1141) Polyclonal Antibody
Applications
- Western Blot (WB)
Tested Dilution: 1:500–1:1,000
Publications: -
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | A synthetic phosphopeptide derived from human Werner Syndrome Helicase around the phosphorylation site of Ser1141 (S-S-SP-Q-P) |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 1 mg/mL |
| Purification | Antigen affinity chromatography |
| Storage Buffer | Dulbecco’s PBS, pH 7.4, with 50% glycerol |
| Contains | 0.02% sodium azide |
| Storage Conditions | -20°C |
| Shipping Conditions | Wet ice |
| RRID | AB_2555524 |
Target Information
This gene encodes a member of the RecQ subfamily and the DEAH (Asp-Glu-Ala-His) subfamily of DNA and RNA helicases. DNA helicases are involved in many aspects of DNA metabolism, including transcription, replication, recombination, and repair.
This protein contains a nuclear localization signal in the C-terminus and shows a predominant nucleolar localization. It possesses intrinsic 3′ to 5′ DNA helicase activity and also a 3′ to 5′ exonuclease activity.
Based on interactions between this protein and Ku70/80 heterodimer in DNA end processing, it may be involved in the repair of double-strand DNA breaks.
Defects in this gene cause Werner syndrome, an autosomal recessive disorder characterized by premature aging.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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