Thermo Fisher Scientific PPIA Monoclonal Antibody (1F4-1B5)
Thermo Fisher Scientific의 PPIA Monoclonal Antibody (1F4-1B5)는 인간 PPIA(Cyclophilin A)에 특이적인 마우스 단클론 항체입니다. Western blot과 ELISA에 적합하며, 보존제가 없는 PBS 용액 형태로 제공됩니다. 연구용 단백질 접힘 및 면역억제 기작 연구에 활용됩니다.
- 카탈로그번호
- H00005478-M01
- 판매단위
- pk
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Applications
Western Blot (WB)
- Tested Dilution: 1–5 µg/mL
ELISA
- Tested Dilution: 0.03 ng/mL
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human |
| Host / Isotype | Mouse / IgG2a, kappa |
| Class | Monoclonal |
| Type | Antibody |
| Clone | 1F4-1B5 |
| Immunogen | PPIA (AAH00689.1, 1–165 a.a.) full-length recombinant protein with GST tag (MW of GST tag = 26 kDa) |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | See Label |
| Purification | Affinity chromatography |
| Storage Buffer | PBS, pH 7.4 |
| Contains | No preservative |
| Storage Conditions | −20°C, Avoid Freeze/Thaw Cycles |
| Shipping Conditions | Ambient (domestic); Wet ice (international) |
Product Specific Information
Protein Sequence:
MVNPTVFFDI AVDGEPLGRV SFELFADKVP KTAENFRALS TGEKGFGYKG SCFHRIIPGF MCQGGDFTRH NGTGGKSIYG EKFEDENFIL KHTGPGILSM ANAGPNTNGS QFFICTAKTE WLDGKHVVFG KVKEGMNIVE AMERFGSRNG KTSKKITIAD CGQLE
Target Information
Immunophilins are soluble cytosolic receptors that bind immunosuppressant agents such as cyclosporin A (CsA) or FK506. Proteins that bind FK506 are FK506 Binding Proteins (FKBPs), and those that bind cyclosporin A are cyclophilins (CyP). Both CyP:CsA and FKBP:FK506 complexes inhibit calcineurin, a calcium/calmodulin-dependent phosphatase involved in T-cell activation, explaining their immunosuppressive effects.
Immunophilins function as peptidyl prolyl cis-trans-isomerases (PPIases), accelerating protein folding by catalyzing rearrangement of proline-containing proteins. Within the cyclophilin family, CyPA (also known as CyP-18) is the most abundant and ubiquitous form, found in all vertebrate tissues and particularly in T-cells.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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