Thermo Fisher Scientific PPOX Polyclonal Antibody, MaxPab

Thermo Fisher Scientific PPOX Polyclonal Antibody, MaxPab

Applications

• Western Blot (WB)
  Tested Dilution: 1–5 µg/mL

Product Specifications

Product Specific Information

Sequence of this protein is as follows:
MGRTVVVLGG GISGLAASYH LSRAPCPPKV VLVESSERLG GWIRSVRGPN GAIFELGPRG IRPAGALGAR TLLLVSELGL DSEVLPVRGD HPAAQNRFLY VGGALHALPT GLRGLLRPSP PFSKPLFWAG LRELTKPRGK EPDETVHSFA QRRLGPEVAS LAMDSLCRGV FAGNSRELSI RSCFPSLFQA EQTHRSILLG LLLGAGRTPQ PDSALIRQAL AERWSQWSLR GGLEMLPQAL ETHLTSRGVS VLRGQPVCGL SLQAEGRWKV SLRDSSLEAD HVISAIPASV LSELLPAEAA PLARALSAIT AVSVAVVNLQ YQGAHLPVQG FGHLVPSSED PGVLGIVYDS VAFPEQDGSP PGLRVTVMLG GSWLQTLEAS GCVLSQELFQ QRAQEAAATQ LGLKEMPSHC LVHLHKNCIP QYTLGHWQKL ESARQFLTAH RLPLTLAGAS YEGVAVNDCI ESGRQAAVSV LGTEPNS

Target Information

Protoporphyrinogen oxidase (PPOX) is the penultimate enzyme in the heme biosynthetic pathway, catalyzing the 6-electron oxidation of protoporphyrinogen IX to protoporphyrin IX. PPOX localizes to the inner mitochondrial membrane in various tissues such as heart, brain, placenta, lung, liver, skeletal muscle, kidney, and pancreas.
Genetic deficiency of PPOX results in variegate porphyria, an autosomal dominant disorder characterized by cutaneous photosensitivity and neurological manifestations. The rare homozygous variant leads to severe PPOX deficiency, causing early onset photosensitization, skeletal abnormalities, and sometimes short stature, mental retardation, and convulsions.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.

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