Thermo Fisher Scientific GART Recombinant Rabbit Monoclonal Antibody (SC66-02)

Applications and Tested Dilutions

Product Specifications

Product Specific Information

Recombinant rabbit monoclonal antibodies are produced using in vitro expression systems by cloning specific antibody DNA sequences from immunoreactive rabbits. Individual clones are screened to select the best candidates for production.
Advantages include:

• Enhanced specificity and sensitivity
• Lot-to-lot consistency
• Animal origin-free formulation
• Broader immunoreactivity due to the rabbit immune repertoire

Target Information

MERTK is a receptor tyrosine kinase that mediates signal transduction from the extracellular matrix into the cytoplasm by binding to ligands such as LGALS3, TUB, TULP1, or GAS6. It regulates various physiological processes including cell survival, migration, differentiation, and phagocytosis of apoptotic cells (efferocytosis). Ligand binding induces autophosphorylation of MERTK, providing docking sites for downstream signaling molecules.
Activated MERTK interacts with GRB2 or PLCG2 and induces phosphorylation of MAPK1, MAPK2, FAK/PTK2, or RAC1. It plays roles in macrophage clearance, platelet aggregation, cytoskeleton reorganization, and retinal pigment epithelium phagocytosis. MERTK also inhibits Toll-like receptor (TLR)-mediated innate immune responses by activating STAT1, leading to SOCS1 and SOCS3 production.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.