Thermo Fisher Scientific GART Recombinant Rabbit Monoclonal Antibody (SC66-02)
GART 단백질을 인식하는 토끼 유래 재조합 단클론 항체. Western blot, IHC, ICC/IF에 사용 가능. 높은 특이성과 재현성을 제공하며, Protein A 정제 및 1 mg/mL 농도의 액상 형태로 공급. 연구용으로만 사용 가능.
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Applications and Tested Dilutions
| Application | Tested Dilution |
|---|---|
| Western Blot (WB) | 1:500 |
| Immunohistochemistry (Paraffin) (IHC (P)) | 1:50–1:200 |
| Immunocytochemistry (ICC/IF) | 1:50–1:200 |
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human, Mouse, Rat |
| Host / Isotype | Rabbit / IgG |
| Expression System | HEK293 cells |
| Class | Recombinant Monoclonal |
| Type | Antibody |
| Clone | SC66-02 |
| Immunogen | Recombinant protein within Human GART aa 570–750 |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 1 mg/mL |
| Purification | Protein A |
| Storage Buffer | TBS, pH 7.4, with 40% Glycerol, 0.05% BSA |
| Contains | 0.05% sodium azide |
| Storage Conditions | Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles. |
| Shipping Conditions | Wet ice |
| RRID | AB_2809520 |
Product Specific Information
Recombinant rabbit monoclonal antibodies are produced using in vitro expression systems by cloning specific antibody DNA sequences from immunoreactive rabbits. Individual clones are screened to select the best candidates for production.
Advantages include:
- Enhanced specificity and sensitivity
- Lot-to-lot consistency
- Animal origin-free formulation
- Broader immunoreactivity due to the rabbit immune repertoire
Target Information
MERTK is a receptor tyrosine kinase that mediates signal transduction from the extracellular matrix into the cytoplasm by binding to ligands such as LGALS3, TUB, TULP1, or GAS6. It regulates various physiological processes including cell survival, migration, differentiation, and phagocytosis of apoptotic cells (efferocytosis). Ligand binding induces autophosphorylation of MERTK, providing docking sites for downstream signaling molecules.
Activated MERTK interacts with GRB2 or PLCG2 and induces phosphorylation of MAPK1, MAPK2, FAK/PTK2, or RAC1. It plays roles in macrophage clearance, platelet aggregation, cytoskeleton reorganization, and retinal pigment epithelium phagocytosis. MERTK also inhibits Toll-like receptor (TLR)-mediated innate immune responses by activating STAT1, leading to SOCS1 and SOCS3 production.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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