Thermo Fisher Scientific Catenin alpha-1 Polyclonal Antibody
Catenin alpha-1 단백질을 인식하는 Thermo Fisher Scientific의 Rabbit Polyclonal Antibody. Western blot, IHC, IP 등 다양한 응용에 사용 가능. Human, Mouse, Rat에 반응하며 항원 친화 크로마토그래피로 정제됨. 연구용으로만 사용.
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Applications and Tested Dilutions
| Application | Tested Dilution |
|---|---|
| Western Blot (WB) | 1:500–1:10,000 |
| Immunohistochemistry (Paraffin) (IHC (P)) | 1:100–1:1,000 |
| Immunoprecipitation (IP) | Assay-dependent |
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human, Mouse, Rat |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | Recombinant fragment corresponding to a region within amino acids 511–906 of Human alpha Catenin |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 1 mg/mL |
| Purification | Antigen affinity chromatography |
| Storage Buffer | PBS, pH 7, with 20% glycerol |
| Contains | 0.01% thimerosal, 0.025% ProClin 300 |
| Storage Conditions | Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles. |
| Shipping Conditions | Wet ice |
| RRID | AB_2545821 |
Product Specific Information
- Recommended positive controls: 293T, A431, mouse brain, rat brain
- Predicted reactivity: Mouse (100%), Rat (100%), Zebrafish (93%), Xenopus laevis (96%), Rabbit (100%), Rhesus Monkey (99%), Bovine (100%)
- Store product as a concentrated solution. Centrifuge briefly prior to opening the vial.
Target Information
Catenin alpha-1은 다양한 cadherin의 세포질 도메인과 결합하며, cadherin-catenin 복합체를 형성하여 액틴 필라멘트 네트워크와 연결됩니다. 이 복합체는 세포 간 부착(adherens junction)에서 중요한 역할을 합니다.
CTNNA1은 E- 및 N-cadherin 모두와 결합할 수 있으며, actin filament 조립을 조절하고 Arp2/3 복합체와의 경쟁을 통해 actin branching을 억제할 수 있습니다. 세포 분화 과정에서 중요한 역할을 수행합니다.
⚠ WARNING
This product can expose you to chemicals including mercury, which is known to the State of California to cause birth defects or other reproductive harm.
For more information, visit www.P65Warnings.ca.gov.
For Research Use Only.
Not for use in diagnostic procedures. Not for resale without express authorization.
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