Thermo Fisher Scientific Mitofilin Polyclonal Antibody
Mitofilin 단백질을 인식하는 Rabbit Polyclonal Antibody로 인간, 생쥐, 랫트에 반응합니다. WB, IHC, ELISA에 사용 가능하며 고순도 Affinity Chromatography로 정제되었습니다. 미토콘드리아 내막 단백질 연구에 적합합니다.
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- PA589627
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Applications
| Application | Tested Dilution | Publications |
|---|---|---|
| Western Blot (WB) | 1:500–1:2,000 | View 1 publication |
| Immunohistochemistry (Paraffin) (IHC (P)) | 1:50–1:200 | - |
| ELISA | 1 µg/mL | - |
Product Specifications
| Specification | Description |
|---|---|
| Species Reactivity | Human, Mouse, Rat |
| Published Species | Human |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | Synthetic peptide corresponding to amino acids 300–400 of human IMMT (NP_0068302) |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 0.64 mg/mL |
| Purification | Affinity Chromatography |
| Storage Buffer | PBS, pH 7.3, with 50% glycerol |
| Contains | 0.02% sodium azide |
| Storage Conditions | -20°C, Avoid Freeze/Thaw Cycles |
| Shipping Conditions | Wet ice |
| RRID | AB_2805695 |
Product Specific Information
- Positive Samples: SW480, SW620, H460, HepG2, Mouse spleen, Mouse testis
- Cellular Location: Mitochondrion, Mitochondrion inner membrane, Single-pass membrane protein
Immunogen sequence:
EELEKMKSVI ENAKKKEVAG AKPHITAAEG KLHNMIVDLD NVVKKVQAAQ SEAKVVSQYH ELVVQARDDF KRELDSITPE VLPGWKGMSV SDLADKLSTD D
Target Information
Mitofilin is a transmembrane protein of the inner mitochondrial membrane associated with a large multimeric protein complex (~1200 kDa). It plays a critical role in mitochondrial morphology, fusion, and fission, particularly in the formation of tubular cristae and cristae junctions. Abnormal mitochondrial morphology is linked to various human diseases such as myopathy, cardiomyopathy, rhabdomyosarcoma, and Whartin's tumor.
For Research Use Only.
Not for use in diagnostic procedures. Not for resale without express authorization.
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