Thermo Fisher Scientific F13B Monoclonal Antibody (OTI1A3), TrueMAB
인간 F13B 단백질(아미노산 357-661)을 면역원으로 제작된 마우스 단클론 항체. Western blot에 1:500 희석으로 사용 가능. 동결건조 형태로 제공되며 PBS, 8% 트레할로스 완충액에 용해. 연구용으로 혈액 응고 인자 XIII B 서브유닛 검출에 적합.
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Applications
- Western Blot (WB): Tested dilution 1:500
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human |
| Host / Isotype | Mouse / IgG1 |
| Class | Monoclonal |
| Type | Antibody |
| Clone | OTI1A3 |
| Immunogen | Human recombinant protein fragment corresponding to amino acids 357–661 of human F13B produced in E. coli |
| Conjugate | Unconjugated |
| Form | Lyophilized |
| Concentration | 1 mg/mL |
| Purification | Affinity chromatography |
| Storage Buffer | PBS, pH 7.3, with 8% trehalose |
| Contains | No preservative |
| Storage Conditions | -20°C, Avoid Freeze/Thaw Cycles |
| Shipping Conditions | Ambient (domestic); Wet ice (international) |
Product Specific Information
For reconstitution, add 100 µL distilled water to obtain a final antibody concentration of approximately 1 mg/mL.
For conjugation experiments, perform an additional desalting step (e.g., Zeba Spin Desalting Columns, 7K MWCO, 0.5 mL, Product #89882).
Target Information
This gene encodes the coagulation factor XIII B subunit. Coagulation factor XIII is the last zymogen activated in the blood coagulation cascade. Plasma factor XIII is a heterotetramer composed of two A subunits and two B subunits. The A subunits have catalytic function, while the B subunits serve as plasma carrier molecules. Platelet factor XIII consists only of two A subunits identical to those of plasma origin. Upon activation by thrombin and calcium ions, plasma factor XIII dissociates its B subunits, yielding the active enzyme factor XIIIa, which acts as a transglutaminase to catalyze crosslinking between fibrin molecules, stabilizing the fibrin clot.
Factor XIII deficiency can result in a lifelong bleeding tendency, defective wound healing, and habitual abortion.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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