Thermo Fisher Scientific F13B Monoclonal Antibody (OTI2H10), TrueMAB

Applications

• Western Blot (WB): Tested dilution 1:200

Product Specifications

Product Specific Information

For reconstitution, add 100 µL distilled water to obtain a final antibody concentration of approximately 1 mg/mL.
For conjugation experiments, perform an additional desalting step using Zeba Spin Desalting Columns (7K MWCO, 0.5 mL, Product #89882).

Target Information

This gene encodes the coagulation factor XIII B subunit. Coagulation factor XIII is the final zymogen activated in the blood coagulation cascade. Plasma factor XIII is a heterotetramer composed of two A subunits (catalytic) and two B subunits (non-enzymatic carrier molecules). Platelet factor XIII contains only two A subunits identical to those in plasma. Upon thrombin activation in the presence of calcium ions, the B subunits dissociate, producing the active enzyme factor XIIIa, which acts as a transglutaminase to catalyze crosslinking between fibrin molecules, stabilizing the clot.
Factor XIII deficiency includes:

• Type I deficiency: Lack of both A and B subunits
• Type II deficiency: Lack of A subunit only
  These conditions can cause lifelong bleeding tendency, impaired wound healing, and habitual abortion.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.