Thermo Fisher Scientific F13B Monoclonal Antibody (OTI2H10), TrueMAB
Human F13B 단백질(aa 357-661)에 특이적인 Mouse Monoclonal Antibody(OTI2H10). Western blot에 적합하며, 동결건조 형태로 제공. PBS buffer(8% trehalose)로 안정화되어 있으며, -20°C 보관 권장. 연구용으로만 사용 가능.
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Applications
- Western Blot (WB): Tested dilution 1:200
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human |
| Host / Isotype | Mouse / IgG1 |
| Class | Monoclonal |
| Type | Antibody |
| Clone | OTI2H10 |
| Immunogen | Human recombinant protein fragment corresponding to amino acids 357–661 of human F13B produced in E. coli |
| Conjugate | Unconjugated |
| Form | Lyophilized |
| Concentration | 1 mg/mL |
| Purification | Affinity chromatography |
| Storage Buffer | PBS, pH 7.3, with 8% trehalose |
| Contains | No preservative |
| Storage Conditions | -20°C, Avoid Freeze/Thaw Cycles |
| Shipping Conditions | Ambient (domestic); Wet ice (international) |
Product Specific Information
For reconstitution, add 100 µL distilled water to obtain a final antibody concentration of approximately 1 mg/mL.
For conjugation experiments, perform an additional desalting step using Zeba Spin Desalting Columns (7K MWCO, 0.5 mL, Product #89882).
Target Information
This gene encodes the coagulation factor XIII B subunit. Coagulation factor XIII is the final zymogen activated in the blood coagulation cascade. Plasma factor XIII is a heterotetramer composed of two A subunits (catalytic) and two B subunits (non-enzymatic carrier molecules). Platelet factor XIII contains only two A subunits identical to those in plasma. Upon thrombin activation in the presence of calcium ions, the B subunits dissociate, producing the active enzyme factor XIIIa, which acts as a transglutaminase to catalyze crosslinking between fibrin molecules, stabilizing the clot.
Factor XIII deficiency includes:
- Type I deficiency: Lack of both A and B subunits
- Type II deficiency: Lack of A subunit only
These conditions can cause lifelong bleeding tendency, impaired wound healing, and habitual abortion.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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