Thermo Fisher Scientific CD290 (TLR10) Monoclonal Antibody (3C10C5), PE, eBioscience
인간 CD290(TLR10)을 인식하는 단클론 항체로, PE 형광 표지되어 흐름세포분석(Flow Cytometry)에 적합합니다. B세포, 단핵구, 조절 T세포 등에서 발현되는 TLR10 검출에 사용됩니다. 친화 크로마토그래피로 정제되었으며, 4°C 암소 보관 권장.
- 카탈로그번호
- 12-2909-42
- 판매단위
- pk
카탈로그
1개 옵션 · 카탈로그 번호를 클릭하면 복사됩니다Thermo Fisher Scientific · Thermo Fisher Scientific CD290 (TLR10) Monoclonal Antibody (3C10C5), PE, eBioscience
Applications and Tested Dilution
| Application | Tested Dilution |
|---|---|
| Flow Cytometry (Flow) | 5 µL (0.25 µg)/test |
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human |
| Published Species | Human |
| Host / Isotype | Mouse / IgG1, kappa |
| Recommended Isotype Control | Mouse IgG1 kappa Isotype Control (P3.6.2.8.1), PE, eBioscience™ |
| Class | Monoclonal |
| Type | Antibody |
| Clone | 3C10C5 |
| Conjugate | PE (R-Phycoerythrin) |
| Excitation / Emission Max | 565 / 576 nm |
| Form | Liquid |
| Concentration | 5 µL/Test |
| Purification | Affinity chromatography |
| Storage Buffer | PBS, pH 7.2, with 0.2% BSA |
| Contains | 0.09% sodium azide |
| Storage Conditions | 4°C, store in dark, DO NOT FREEZE |
| Shipping Conditions | Ambient (domestic); Wet ice (international) |
| RRID | AB_2572599 |
Product Specific Information
Description:
This 3C10C5 monoclonal antibody reacts with human CD290, also known as Toll-like receptor 10 (TLR10). This type I transmembrane glycoprotein is expressed on B cells, monocytes, regulatory T cells (Tregs), and plasmacytoid dendritic cells. CD290 expression depends on Foxp3 and NFAT in Tregs. CD290 can self-dimerize and heterodimerize with other TLR family members such as TLR1 and TLR2. Ligand binding leads to association with the adapter molecule MyD88 and activation of signaling pathways. Although ligands remain undefined, CD290 is associated with immune responses against microbial and fungal infections and autoimmune diseases such as Crohn’s disease and systemic lupus erythematosus.
Applications Reported:
This 3C10C5 antibody is reported for use in flow cytometric analysis.
Applications Tested:
Pre-titrated and tested by flow cytometric analysis of normal human peripheral blood cells. Recommended usage: 5 µL (0.25 µg) per test. A test is defined as the amount of antibody that stains a cell sample in a final volume of 100 µL. Cell number may range from 10⁵ to 10⁸ cells/test.
Optical Properties:
Excitation: 488–561 nm
Emission: 578 nm
Compatible Lasers: Blue, Green, Yellow-Green
Filtration:
0.2 µm post-manufacturing filtered.
Target Information
The protein encoded by this gene belongs to the Toll-like receptor (TLR) family, which plays a key role in pathogen recognition and innate immunity activation. TLRs are conserved from Drosophila to humans, recognizing pathogen-associated molecular patterns (PAMPs) on infectious agents and mediating cytokine production for effective immunity. TLR10 is highly expressed in lymphoid tissues such as spleen, lymph node, thymus, and tonsil. Multiple alternatively spliced transcript variants encoding the same protein have been identified.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
제품 이미지
Thermo Fisher Scientific 상품 둘러보기
전체보기
문의
0개 · 배송·재고 문의는 실시간 상담이 빠릅니다아직 등록된 문의가 없어요.