Thermo Fisher Scientific Androgen Receptor (Marker of Androgen Dependence) Monoclonal Antibody (SPM335)

Applications and Tested Dilution

Product Specifications

Product Specific Information

• Does not react with Mouse.

Target Information

The androgen receptor (AR) is a member of the steroid-hormone receptor superfamily of nuclear receptors. The receptor (~90 kDa) contains three major functional domains: the N-terminal domain, DNA-binding domain, and androgen-binding domain.
AR is a ligand-activated transcription factor that binds testosterone (T) and dihydrotestosterone (DHT). Upon ligand binding, AR dissociates from accessory proteins, translocates to the nucleus, dimerizes, and activates transcription of androgen-responsive genes.
The AR signaling pathway is essential for the development and function of male reproductive organs (prostate, epididymis) and also affects non-reproductive tissues such as muscle, hair follicles, and brain.
AR is a phosphoprotein that regulates MAP kinase activity; inhibition of MEK1/2 correlates with AR phosphorylation changes.
Abnormal AR signaling is linked to diseases including prostate cancer, Kennedy’s disease, and male infertility. Mutations in AR cause complete androgen insensitivity syndrome (CAIS).

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.