Thermo Fisher Scientific Androgen Receptor (Marker of Androgen Dependence) Monoclonal Antibody (SPM335)
인간 안드로겐 수용체(AR)를 특이적으로 인식하는 단클론 항체로 다양한 면역분석(IHC, ICC, Flow Cytometry)에 사용 가능. 단백질 A/G 정제, 액상 형태로 제공되며 보존제가 없음. 연구용으로만 사용, 진단용 불가.
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Applications and Tested Dilutions
| Application | Tested Dilution |
|---|---|
| Immunohistochemistry (Paraffin) (IHC (P)) | Assay-dependent |
| Immunohistochemistry (PFA fixed) (IHC (PFA)) | 1–2 µg/mL |
| Immunocytochemistry (ICC/IF) | 1–2 µg/mL |
| Flow Cytometry (Flow) | 1–2 µg/10^6 cells |
Product Specifications
| Property | Description |
|---|---|
| Species Reactivity | Human |
| Host / Isotype | Mouse / IgG1, kappa |
| Class | Monoclonal |
| Type | Antibody |
| Clone | SPM335 |
| Immunogen | Synthetic peptide, aa 302–318 (STEDTAEYSPFKGGYTK) of human AR |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 1 mg/mL |
| Purification | Protein A/G |
| Storage Buffer | PBS, pH 7.4 |
| Contains | No preservative |
| Storage Conditions | −20°C, Avoid freeze/thaw cycles |
| Shipping Conditions | Ambient (domestic); Wet ice (international) |
Product Specific Information
Does not react with Mouse.
Target Information
The androgen receptor (AR) is a member of the steroid-hormone receptor superfamily of nuclear receptors. It is a ligand-activated transcription factor that binds active testosterone (T) and dihydrotestosterone (DHT). Upon ligand binding, the receptor translocates into the nucleus, dimerizes, and stimulates transcription of androgen-responsive genes.
AR signaling is crucial for development and function of male reproductive organs (prostate, epididymis) and also plays roles in muscle, hair follicles, and brain.
Abnormalities in AR signaling are linked to diseases such as prostate cancer, Kennedy’s disease, and male infertility. Mutations can cause complete androgen insensitivity (CAIS).
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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