Thermo Fisher Scientific CCR1 Polyclonal Antibody
Human CCR1 단백질을 인식하는 Rabbit Polyclonal Antibody로, IHC(P)에서 2.5 µg/mL로 검증됨. 항원 친화 크로마토그래피로 정제되었으며 PBS 버퍼에 0.1% sodium azide 함유. 염증 및 면역세포 이동 연구용으로 적합.
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Applications
- Immunohistochemistry (Paraffin) (IHC (P)): Tested dilution 2.5 µg/mL
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | Synthetic 18 amino acid peptide from N-terminal extracellular domain of human CCR1 |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 1 mg/mL |
| Purification | Antigen affinity chromatography |
| Storage Buffer | PBS |
| Contains | 0.1% sodium azide |
| Storage Conditions | Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles. |
| Shipping Conditions | Ambient (domestic); Wet ice (international) |
| RRID | AB_2550773 |
Product Specific Information
Percent identity with other species by BLAST analysis:
- Human, Gorilla, Gibbon: 100%
- Monkey, Hamster: 89%
- Marmoset, Mouse: 83%
Target Information
Chemokines play important roles in inflammation and are critical for the recruitment of effector immune cells to sites of infection. Chemokines activate leukocytes by binding to G protein coupled receptors. The chemokine receptor subtypes are divided into CXCR and CCR groups.
CCR1 is expressed on neutrophils, monocytes, lymphocytes, and eosinophils. It binds macrophage-inflammatory protein (MIP-1), eotaxin, and other related chemokines.
Mice lacking CCR1 show defects in neutrophil trafficking and proliferation.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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