Thermo Fisher Scientific CD11b/c Monoclonal Antibody (OX-42), Biotin
Rat CD11b/c 인식 단클론 항체(OX-42), Biotin 결합형. Flow cytometry, IHC(F), ICC/IF에 사용 가능. Protein A로 정제된 액상 형태로, PBS(pH 7.2)와 1% BSA 포함. 4°C 단기 보관, -20°C 장기 보관 권장.
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Applications and Tested Dilution
| Application | Tested Dilution | Publications |
|---|---|---|
| Immunohistochemistry (Frozen) (IHC (F)) | Assay-dependent | - |
| Immunocytochemistry (ICC/IF) | - | 1 publication |
| Flow Cytometry (Flow) | Neat-1:10 | - |
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Rat |
| Published Species | Rat |
| Host / Isotype | Mouse / IgG2a |
| Class | Monoclonal |
| Type | Antibody |
| Clone | OX-42 |
| Immunogen | Rat peritoneal macrophages |
| Conjugate | Biotin |
| Form | Liquid |
| Concentration | 0.1 mg/mL |
| Purification | Protein A |
| Storage Buffer | PBS, pH 7.2, with 1% BSA |
| Contains | 0.09% sodium azide |
| Storage Conditions | Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles. |
| Shipping Conditions | Ambient (domestic); Wet ice (international) |
| RRID | AB_927461 |
Additional Formats
Product Specific Information
For FACS analysis, use 10 µL of the suggested working dilution to label 1×10⁶ cells in 100 µL.
Mouse anti-Rat CD11b, clone OX-42, recognizes rat CD11b (integrin alpha-M), the receptor for the iC3b component of complement.
CD11b is a 1151 amino acid single-pass type I transmembrane glycoprotein possessing a single vWFA domain and multiple FG-GAP repeats.
Target Information
Integrins are heterodimeric integral membrane proteins composed of an alpha and a beta chain.
CD11b is involved in adhesive interactions of monocytes, macrophages, and granulocytes, and mediates uptake of complement-coated particles.
It is identical to CR3, the receptor for the iC3b fragment of the third complement component.
CD11b also serves as a receptor for fibrinogen, factor X, and ICAM1, recognizing P1 and P2 peptides of the fibrinogen gamma chain.
The Mac-1 (CD11b) antigen is expressed on macrophages, granulocytes, NK cells, and blood monocytes.
CD11b is expressed on approximately 8% of spleen cells, 44% of bone marrow cells, and less than 1% of thymocytes, and is commonly used as a microglial marker in nervous tissue.
CD11c encodes the integrin alpha X chain protein, which combines with the beta 2 chain (ITGB2) to form the leukocyte-specific integrin inactivated-C3b (iC3b) receptor 4 (CR4).
The alpha X beta 2 complex overlaps with alpha M beta 2 integrin in neutrophil and monocyte adherence to stimulated endothelium and in phagocytosis of complement-coated particles.
Mutations in the CD11b/c gene are associated with systemic lupus erythematosus 6.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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