Thermo Fisher Scientific BACE2 Polyclonal Antibody
BACE2 단백질을 인식하는 Rabbit Polyclonal 항체로, WB 및 IHC에 적합합니다. 인간, 마우스, 랫트 시료에 반응하며, 동결건조 형태로 제공됩니다. APP 절단 관련 연구 및 알츠하이머 질환 연구에 유용합니다.
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- OSB00064W-150UL
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Applications and Tested Dilution
| Application | Tested Dilution |
|---|---|
| Western Blot (WB) | 1:200–1:2,000 |
| Immunohistochemistry (IHC) | 1:200–1:2,000 |
| Miscellaneous PubMed (Misc) | - |
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human, Mouse, Rat |
| Published Species | Not Applicable |
| Host / Isotype | Rabbit / Ig |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | A synthetic peptide from aa region 460–518 of human BACE2 conjugated to an immunogenic carrier protein |
| Conjugate | Unconjugated |
| Form | Lyophilized |
| Concentration | Not Determined |
| Storage Buffer | Whole serum |
| Contains | No preservative |
| Storage Conditions | Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles. Glycerol (1:1) may be added for added stability. |
| Shipping Conditions | Ambient (domestic); Wet ice (international) |
Product Specific Information
Reconstitute in 150 µL of sterile water. Centrifuge to remove any insoluble material.
Specificity of this antibody: BACE2
Target Information
BACE2 (Beta Secretase 2) is responsible for the proteolytic processing of the amyloid precursor protein (APP).
BACE2 cleaves APP between residues 690 and 691, leading to the generation and extracellular release of beta-cleaved soluble APP.
It also cleaves APP between residues 671 and 672.
Accumulation of APP is a signature of Alzheimer’s disease and a frequent complication in adult Down syndrome patients.
For Research Use Only.
Not for use in diagnostic procedures.
Not for resale without express authorization.
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