Thermo Fisher Scientific TRPC6 (extracellular) Polyclonal Antibody, FITC

Applications

• Flow Cytometry (Flow): Tested dilution 5 µg

Product Specifications

Product Specific Information

• Reconstitution: Add 50 µL double distilled water (DDW) depending on sample size.
• Ships as lyophilized powder at room temperature.
• Upon arrival, store at -20°C.
• Reconstituted solution can be stored at 4°C for up to 1 week.
• For long-term storage, aliquot and keep at -20°C.
• Avoid multiple freeze/thaw cycles.
• Centrifuge all antibody preparations before use (10,000 × g, 5 min).

Target Information

Trpc6 forms a receptor-activated calcium channel in the cell membrane. It is activated by diacylglycerol (DAG) and functions independently of protein kinase C. TRPC6 plays a role in phosphatidylinositol-mediated signaling and calcium regulation. Mutations in the TRPC6 gene are associated with focal segmental glomerulosclerosis 2 (FSGS2).
TRPC6 belongs to the “canonical TRP” (TRPC) family, part of the mammalian transient receptor potential (TRP) superfamily. Members of this family are activated through PLC-coupled receptors and act as receptor-regulated cation channels. TRPC6 channels can be activated by DAG analogs, suggesting a PLC-coupled receptor mechanism.
When expressed in transfected cells, TRPC6 acts as a non-selective, store-independent, receptor-activated cation channel. It is DAG-activated, PKC-independent, and insensitive to IP3. Increasing evidence supports TRPC6 as an endogenous DAG-activated receptor-operated cation channel in vivo.
Diseases associated with TRPC6 include Glomerulosclerosis, Focal Segmental, 2 and Focal Segmental Glomerulosclerosis.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.

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