Thermo Fisher Scientific p27 Kip1 Polyclonal Antibody
Rabbit polyclonal antibody targeting human p27 Kip1 protein. Validated for Western blot and immunocytochemistry. Recognizes human and mouse species. Suitable for cell cycle regulation studies. For research use only.
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Applications and Tested Dilutions
| Application | Tested Dilution | Publications |
|---|---|---|
| Western Blot (WB) | 1:1,000 | View 4 publications |
| Immunocytochemistry (ICC/IF) | 1:10–1:50 | View 1 publication |
Product Specifications
| Category | Details |
|---|---|
| Species Reactivity | Human |
| Published Species | Human, Mouse |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | KLH-conjugated synthetic peptide corresponding to amino acids 165–194 of the C-terminal region of human p27 Kip1 |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 0.39 mg/mL |
| Purification | Protein A, Antigen affinity chromatography |
| Storage Buffer | PBS, pH 7.4 |
| Contains | 0.09% sodium azide |
| Storage Conditions | Store at 4°C short term. For long-term storage, store at -20°C, avoiding freeze/thaw cycles. |
| Shipping Conditions | Ambient (domestic); Wet ice (international) |
| RRID | AB_2078006 |
Product Specific Information
This antibody is predicted to react with hamster based on sequence homology.
Target Information
p27 Kip1 functions as a negative regulator of G1 phase progression and acts as a mediator of TGF-β–induced G1 arrest. It is a key regulator of cell cycle progression and a potent inhibitor of cyclin E- and cyclin A-CDK2 complexes. p27 Kip1 forms complexes with cyclin D-CDK4, contributing to assembly, stability, and modulation of CCND1-CDK4 activation. Its activity depends on phosphorylation state and stoichiometry, acting either as an inhibitor or activator. Degradation of p27 Kip1, triggered by CDK-dependent phosphorylation and ubiquitination by SCF complexes, is essential for transition from quiescence to proliferation. The protein has an approximate molecular weight of 27 kDa.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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