Thermo Fisher Scientific Caspase 4 Monoclonal Antibody (17D9)
Caspase 4 단일클론 항체(17D9)는 Western blot, IHC, ICC/IF, IP 등 다양한 응용에 적합합니다. Rat IgG2a 형식의 비결합 액상 항체로, 세포사멸 관련 단백질 검출에 사용됩니다. 장기 보관 시 -20°C에서 냉동 보관 권장.
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Applications and Tested Dilution
| Application | Tested Dilution | Notes |
|---|---|---|
| Western Blot (WB) | 5–10 µg/mL | |
| Immunohistochemistry (Frozen) (IHC (F)) | Assay-dependent | |
| Immunocytochemistry (ICC/IF) | 1:200 | |
| Immunoprecipitation (IP) | Assay-dependent |
Product Specifications
| Property | Description |
|---|---|
| Host / Isotype | Rat / IgG2a |
| Class | Monoclonal |
| Type | Antibody |
| Clone | 17D9 |
| Immunogen | Recombinant p30 subunit of mouse caspase 11 |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 1.4 mg/mL |
| Storage Conditions | Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles. |
| Shipping Conditions | Wet ice |
| RRID | AB_779521 |
Product Specific Information
- Recommended positive controls: EL4
- MA1-24703 is expected to cross-react with rat due to sequence homology.
Target Information
This gene encodes a protein that is a member of the cysteine-aspartic acid protease (caspase) family. Sequential activation of caspases plays a central role in the execution phase of cell apoptosis.
Caspases exist as inactive proenzymes composed of a prodomain and a large and small protease subunit. Activation requires proteolytic processing at conserved internal aspartic residues to generate a heterodimeric enzyme consisting of the large and small subunits.
This caspase can cleave and activate its own precursor protein as well as the caspase 1 precursor. Overexpression of this gene induces cell apoptosis. Alternative splicing results in transcript variants encoding distinct isoforms.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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