Thermo Fisher Scientific IL-2 Monoclonal Antibody (JES6-1A12)

Applications

Immunohistochemistry (Paraffin) (IHC (P))

• Tested Dilution: 2–10 µg/mL

Flow Cytometry (Flow)

• Tested Dilution: 0.5–5 µg/10^6 cells

Product Specifications

Product Specific Information

• Positive control: Bone Marrow
• Cellular location: Secreted

Target Information

Interleukin 2 (IL-2) is an immuno-modulatory cytokine important for the proliferation of activated T cells, differentiation of B cells, natural killer cells, monocytes, and macrophages. IL-2 signals through the IL-2 receptor (IL-2R), a heterotrimeric protein complex whose gamma chain is also shared by interleukin 4 (IL-4) and interleukin 7 (IL-7). Expression of the IL-2 gene in mature thymocytes is monoallelic, representing an unusual regulatory mode for precise gene expression. Targeted disruption of a gene similar to IL-2 in mice leads to an ulcerative colitis-like disease, indicating an essential role in immune response to antigenic stimuli.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.