Thermo Fisher Scientific Perforin Monoclonal Antibody (dG9)
Human Perforin 단백질을 인식하는 Mouse IgG2b 단일클론 항체. Western blot 및 파라핀 포매 조직면역염색에 적합. Protein A 정제, 액상 형태로 제공되며 안정화제가 포함된 PBS 버퍼에 보관. 세포막 및 분비 위치의 perforin 검출에 유용.
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Applications and Tested Dilution
| Application | Tested Dilution |
|---|---|
| Western Blot (WB) | 0.1–1 µg/mL |
| Immunohistochemistry (Paraffin) (IHC (P)) | 2–10 µg/mL |
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human |
| Host / Isotype | Mouse / IgG2b |
| Class | Monoclonal |
| Type | Antibody |
| Clone | dG9 |
| Immunogen | Recombinant protein of human Perforin |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 0.5 mg/mL |
| Purification | Protein A |
| Storage Buffer | PBS with proprietary stabilizer |
| Contains | 0.01% sodium azide |
| Storage Conditions | Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles. |
| Shipping Conditions | Ambient (domestic); Wet ice (international) |
Product Specific Information
- Positive control: Spleen
- Cellular location: Secreted, Cell membrane
Target Information
Perforin is a major cytolytic protein found in cytolytic granules. It acts as a cytolytic mediator released by cytotoxic lymphocytes to defend against tumors and viral infections. The protein consists of 555 amino acids, including a 21 amino acid signal peptide, with a molecular weight of approximately 70–75 kDa. Perforin functions as a pore-forming protein, similar in mechanism to complement component C9, with demonstrated homology between the two.
Perforin expression is restricted to killer cell lines and absent in helper T lymphocytes or other tumor cells. It is a key effector molecule in T-cell and natural killer (NK) cell-mediated cytolysis. Mutations in the perforin gene are associated with familial hemophagocytic lymphohistiocytosis type 2 (HPLH2), a rare and lethal autosomal recessive disorder of early childhood. Alternative splicing results in multiple transcript variants of perforin.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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