Thermo Fisher Scientific CXCR5 Recombinant Rabbit Monoclonal Antibody (9Q10I2)
CXCR5 단백질을 인식하는 재조합 토끼 단클론 항체로, Western blot, ICC/IF, ELISA에 사용 가능. 인간, 마우스, 랫트 반응성. HEK293 세포에서 발현된 IgG 형식의 비결합 항체. B세포 이동 연구 및 GPCR 관련 연구에 적합.
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Applications and Tested Dilution
| Application | Tested Dilution |
|---|---|
| Western Blot (WB) | 1:1,000–1:2,000 |
| Immunocytochemistry (ICC/IF) | 1:100–1:1,000 |
| ELISA | 1 µg/mL |
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human, Mouse, Rat |
| Host / Isotype | Rabbit / IgG |
| Expression System | HEK293 cells |
| Class | Recombinant Monoclonal |
| Type | Antibody |
| Clone | 9Q10I2 |
| Immunogen | Synthetic peptide corresponding to amino acids 273–372 of human CXCR5 (P32302) |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 0.4 mg/mL |
| Purification | Affinity Chromatography |
| Storage Buffer | PBS, pH 7.3, with 0.05% BSA, 50% glycerol |
| Contains | 0.02% sodium azide |
| Storage Conditions | -20°C, Avoid Freeze/Thaw Cycles |
| Shipping Conditions | Ambient (domestic); Wet ice (international) |
| RRID | AB_2912041 |
Product Specific Information
- Positive test controls: Jurkat, K-562, Mouse lung, Mouse spleen, Mouse thymus, Rat thymus
- Localization: Cell membrane, Multi-pass membrane protein
Immunogen sequence:
SPYHIVIFLD TLARLKAVDN TCKLNGSLPV AITMCEFLGL AHCCLNPMLY TFAGVKFRSD LSRLLTKLGC TGPASLCQLF PSWRRSSLSE SENATSLTTF
Target Information
CXCR5 (C-X-Chemokine Receptor Type 5, CD185)
CXCR5, also known as Burkitt lymphoma receptor 1 (BLR1), belongs to the CXC chemokine receptor family. It is a G protein-coupled seven transmembrane receptor for chemokine BLC and is specifically expressed in Burkitt’s lymphoma and lymphatic tissues such as lymph node follicles and spleen. CXCR5 plays an essential role in B cell migration.
CXCR5 expression has been observed in human blood, salivary glands, and various animal tissues including lymphatic organs, bone marrow, brain, liver, lymph node, skin, spleen, stomach, and tonsil. ESTs have been isolated from human brain, germ cell, lung, lymph, and pancreas.
G-protein Coupled Receptors (GPCRs) share a structural motif of seven transmembrane helices and exist in both active and inactive forms. They are key targets in pharmacological research, with notable GPCR-targeted drugs including Zyprexa (Eli Lilly) and Claritin (Schering-Plough).
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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