Thermo Fisher Scientific PDZK1 Recombinant Rabbit Monoclonal Antibody (5C1D3)

Applications

Tested Dilution

Publications

Immunocytochemistry (ICC/IF)

1:50-1:200

-

ELISA (ELISA)

1 µg/mL

-

Product Specifications

Species Reactivity

Human, Mouse, Rat

Host/Isotype

Rabbit / IgG

Expression System

HEK293 cells

Class

Recombinant Monoclonal

Type

Antibody

Clone

5C1D3

Immunogen

A synthetic peptide corresponding to a sequence within amino acids 420-519 of human PDZK1 (Q5T2W1). if (typeof window.$mangular === undefined || !window.$mangular) { window.$mangular = {}; } $mangular.antigenJson = \[{targetFamily:PDZK1,uniProtId:Q5T2W1-1,ncbiNodeId:9606,antigenRange:420-519,antigenLength:519,antigenImageFileName:MA5-42898_PDZK1_Q5T2W1-1_Rabbit.svg,antigenImageFileNamePDP:MA5-42898_PDZK1_Q5T2W1-1_Rabbit_PDP.jpeg,sortOrder:1}\]; $mangular.isB2BCMGT = false; $mangular.isEpitopesModalImageMultiSizeEnabled = true;

View immunogen .st0{fill:#FFFFFF;} .st1{fill:#1E8AE7;}

Conjugate

Unconjugated Unconjugated Unconjugated

Form

Liquid

Concentration

0.49 mg/mL

Purification

Affinity Chromatography

Storage buffer

PBS, pH 7.3, with 0.05% BSA, 50% glycerol

Contains

0.02% sodium azide

Storage conditions

-20° C, Avoid Freeze/Thaw Cycles

Shipping conditions

Ambient (domestic); Wet ice (international)

RRID

AB_2912039

Product Specific Information

Positive test controls include: HepG2.

Immunogen sequence: EDVIIEVNGV NVLDEPYEKV VDRIQSSGKN VTLLVCGKKA YDYFQAKKIP IVSSLADPLD TPPDSKEGIV VESNHDSHMA KERAHSTASH SSSNSEDTEM

Target Information

PDZK1 is a scaffold protein that connects plasma membrane proteins and regulatory components, regulating their surface expression in epithelial cells apical domains. It may be involved in the coordination of a diverse range of regulatory processes for ion transport and second messenger cascades. In complex with SLC9A3R1, it may cluster proteins that are functionally dependent in a mutual fashion and modulate the trafficking and the activity of the associated membrane proteins. It may also play a role in the cellular mechanisms associated with multidrug resistance through its interaction with ABCC2 and PDZK1IP1. May potentiate the CFTR chloride channel activity. PDZK1 functions to connect SCARB1 with the cellular machineries for intracellular cholesterol transport and/or metabolism and may be involved in the regulation of proximal tubular Na(+)-dependent inorganic phosphate cotransport therefore playing an important role in tubule function.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.