Thermo Fisher Scientific HIRA Recombinant Rabbit Monoclonal Antibody (6Q7Y6)

Applications

Tested Dilution

Publications

Western Blot (WB)

1:500-1:1,000

-

ELISA (ELISA)

1 µg/mL

-

Product Specifications

Species Reactivity

Human

Host/Isotype

Rabbit / IgG

Expression System

HEK293 cells

Class

Recombinant Monoclonal

Type

Antibody

Clone

6Q7Y6

Immunogen

Recombinant fusion protein containing a sequence corresponding to amino acids 550-675 of human HIRA (P54198). if (typeof window.$mangular === undefined || !window.$mangular) { window.$mangular = {}; } $mangular.antigenJson = \[{targetFamily:HIRA,uniProtId:P54198-1,ncbiNodeId:9606,antigenRange:550-675,antigenLength:1017,antigenImageFileName:MA5-42899_HIRA_P54198-1_Rabbit.svg,antigenImageFileNamePDP:MA5-42899_HIRA_P54198-1_Rabbit_PDP.jpeg,sortOrder:1}\]; $mangular.isB2BCMGT = false; $mangular.isEpitopesModalImageMultiSizeEnabled = true;

View immunogen .st0{fill:#FFFFFF;} .st1{fill:#1E8AE7;}

Conjugate

Unconjugated Unconjugated Unconjugated

Form

Liquid

Concentration

1.5 mg/mL

Purification

Affinity Chromatography

Storage buffer

PBS, pH 7.3, with 0.05% BSA, 50% glycerol

Contains

0.02% sodium azide

Storage conditions

-20° C, Avoid Freeze/Thaw Cycles

Shipping conditions

Ambient (domestic); Wet ice (international)

RRID

AB_2912040

Product Specific Information

Positive test controls include: HeLa, 293T.

Immunogen sequence: PSVLTTPSKI EPMKAFDSRF TERSKATPGA PALTSMTPTA VERLKEQNLV KELRPRDLLE SSSDSDEKVP LAKASSLSKR KLELEVETVE KKKKGRPRKD SRLMPVSLSV QSPAALTAEK EAMCLS

Target Information

HIRA is a histone chaperone that preferentially places the variant histone H3.3 in nucleosomes. Orthologs of this protein in yeast, flies, and plants are necessary for the formation of transcriptionally silent heterochromatin. It plays an important role in the formation of the senescence-associated heterochromatin foci. These foci likely mediate the irreversible cell cycle changes that occur in senescent cells. It is considered the primary candidate protein in some haploinsufficiency syndromes such as DiGeorge syndrome, and insufficient production of the gene may disrupt normal embryonic development.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.