Thermo Fisher Scientific BRAF Monoclonal Antibody (OTI3E8), TrueMAB

Applications

Product Specifications

Product Specific Information

For reconstitution, add 100 µL distilled water to achieve a final antibody concentration of approximately 1 mg/mL.
For conjugation experiments using carrier-free antibody, perform an additional desalting step (e.g., Zeba Spin Desalting Columns, 7K MWCO, 0.5 mL, Product #89882).

Target Information

BRAF is involved in transducing mitogenic signals from the cell membrane to the nucleus. It is activated by somatic point mutations in human cancers and contributes to postsynaptic responses in hippocampal neurons.
BRAF regulates the MAP kinase/ERKs signaling pathway, influencing cell division, differentiation, and secretion.
Mutations in BRAF are associated with various cancers, including non-Hodgkin lymphoma, colorectal cancer, malignant melanoma, thyroid carcinoma, non-small cell lung carcinoma, and lung adenocarcinoma.
A pseudogene for BRAF is located on chromosome X.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.