Thermo Fisher Scientific BRAF Monoclonal Antibody (OTI4C5), TrueMAB

Applications

Western Blot (WB)

• Tested Dilution: 1:2,000

Immunoprecipitation (IP)

• Tested Dilution: Assay-dependent

Product Specifications

Product Specific Information

For reconstitution, add 100 µL distilled water to achieve a final antibody concentration of approximately 1 mg/mL.
For conjugation experiments using this carrier-free antibody, perform an additional desalting step (Zeba Spin Desalting Columns, 7K MWCO, 0.5 mL, Product #89882).

Target Information

BRAF is involved in transmitting mitogenic signals from the cell membrane to the nucleus. It is activated by somatic point mutations in human cancers and plays a role in postsynaptic responses of hippocampal neurons.
BRAF regulates the MAP kinase/ERKs signaling pathway, influencing cell division, differentiation, and secretion.
Mutations in BRAF are associated with various cancers, including non-Hodgkin lymphoma, colorectal cancer, malignant melanoma, thyroid carcinoma, non-small cell lung carcinoma, and lung adenocarcinoma.
A pseudogene located on chromosome X has also been identified for BRAF.

For Research Use Only.
Not for use in diagnostic procedures. Not for resale without express authorization.

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