Thermo Fisher Scientific GLRB Polyclonal Antibody
GLRB 단백질을 인식하는 Rabbit Polyclonal 항체로, Western blot에 적합합니다. Human, Mouse, Rat 시료 반응성이 있으며, 항원 친화 크로마토그래피로 정제되었습니다. 1 mg/mL 농도의 액상 형태로 제공되며, 연구용으로만 사용 가능합니다.
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Applications
- Western Blot (WB): 1:500–1:1,000
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human, Mouse, Rat |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | Synthetic peptide corresponding to amino acids 252–297 of human GLRB |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 1 mg/mL |
| Purification | Antigen affinity chromatography |
| Storage buffer | PBS, pH 7.2 |
| Contains | 0.02% sodium azide |
| Storage conditions | Store at 4°C (short term). For long-term storage, store at –20°C, avoiding freeze/thaw cycles. |
| Shipping conditions | Ambient (domestic); Wet ice (international) |
| RRID | AB_2553835 |
Product Specific Information
- Detects endogenous GLRB protein (~58 kDa).
- Purity >95% by SDS-PAGE.
Target Information
In the central nervous system (CNS), glycine-mediated inhibitory neurotransmission is essential for voluntary motor control and reflex responses. Glycine binds to glycine receptors (GlyR) in postsynaptic neuronal membranes. GlyR, together with gamma-aminobutyric acid, serotonin, and acetylcholine receptors, belongs to an evolutionarily conserved superfamily of ligand-gated ion channels.
The pentameric subunit structure of GlyR consists of glycosylated membrane proteins (α1–α4 and β) forming a chloride-selective ion channel. In humans, the composition changes from α2 subunits in the fetal CNS to α1 and β subunits in the adult CNS. Fast potentiation of GlyR by intracellular Ca²⁺ in the brainstem and midbrain indicates an important role for Ca²⁺ in modulation of glycinergic synapses.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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